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Comparison of 25 Microgram of Sublingual Misoprostol with 25 Microgram Vaginal Misoprostol for Induction of Labour at Term

NachimuthuVanathi, Assistant Professor, Department of Obstetrics and Gynecology, Chennai Medical College Hospital & Research Center, Irungalur, Trichy, Tamil Nadu 621105, India. , Nachimuthu Vanathi* , Balasubramanian Saranya*

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Indian Journal of Obstetrics and Gynecology 6(1):p 65-70, Jan-Feb 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6118.12

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Abstract

Introduction: To compare 25 microgram of misoprostol with two different routes [sublingual and vaginal] for induction of labour at term in terms of efficacy, tolerability and safety. Material and Method: After getting approval from ethical committee, 180 patients those for labour induction at term were included in this study. 90 patients were administered sublingual misoprostol and remaining 90 patients were administered vaginal misoprostol after considering inclusion and exclusion criteria. Outcome measures like mode of delivery, induction-delivery interval, maternal complications, fetal outcome and complications were compared using an unpaired, two-tailed Student’s t test and chisquare test. Results: 25 g of sublingual misoprostol patients had shortened induction delivery interval and needed less number of misoprostol tablets and pelvic examination than vaginal misoprostol (p<0.05) with no significant difference in mode of delivery and fetomaternal complications. Conclusion: we conclude that 25 g of sublingual misoprostol is better in efficacy than 25 g of vaginal misoprostol for term induction with no difference in tolerability and safety.

Keywords: Induction; Labour; Misoprostol; Sublingual; Term; Vaginal.

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DOI: DOI: http://dx.doi.org/10.21088/ijog.2321.1636.6118.12

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