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Comparative Study of the Effects of Intravenous Etomidate and Propofol Used for Induction of General Anesthesia

Suhasini Sonavdekar , Ankita Joshi1 , Suhasini Sonavdekar2 , Olvyna D‘Souza3 , Robin Gupta4

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Indian Journal of Anesthesia and Analgesia 6(5):p 1723-1730, September-October 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6519.33

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Ankita Joshi, Suhasini Sonavdekar, Olvyna D‘Souza et al. Comparative Study of the Effects of Intravenous Etomidate and Propofol Used for Induction of General Anesthesia. Indian J Anesth Analg. 2019;6(5 P-II):1723-1730.

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Abstract

Aims and objectives: To compare hemodynamic responses and side effects while induction and intubation with intravenous etomidate and propofol. Material and Methods: We conducted a prospective, randomized, double-blind study, in which 100 patients undergoing elective surgery under general anesthesia were enrolled for the study. Patients were randomly distributed in two groups (50 in each group). Group P received propofol at 2 mg/kg and Group E received etomidate at 0.2 mg/kg. Results: When both the groups were compared it was found out there was statistically significant difference in Group P as compared to Group E in terms of decrease in HR , SBP , DBP, MAP, incidence of myoclonic movements and incidence of pain on injection. There was no overall complication in both groups. Conclusion: Induction of anesthesia with etomidate had more stable hemodynamic conditions as compared to propofol. There was significant reduction in heart rate and blood pressure leading to hypotension in propofol group while etomidate group had stable hemodynamics. Incidence and severity of pain on injection was more with propofol while incidence of myoclonus was more with etomidate. Overall, it was concluded that etomidate was a better choice for induction of anesthesia, only drawback being higher incidence of myoclonus.

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Ankita Joshi, Suhasini Sonavdekar, Olvyna D‘Souza et al. Comparative Study of the Effects of Intravenous Etomidate and Propofol Used for Induction of General Anesthesia. Indian J Anesth Analg. 2019;6(5 P-II):1723-1730.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6519.33

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Hemodynamic responses; Etomidate; Propofol.

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