Ashishjot Kaur Junior Resident, Department of Medicine, Gian Sagar Medical College and Hospital, Ram Nagar, Patiala, Punjab, India
Amritpal Kaur Assistant Professor, Department of Pulmonary Medicine, Gian Sagar Medical College and Hospital, Ram Nagar, Patiala, Punjab,, India
Address for correspondence: Ashishjot Kaur, Junior Resident, Department of Medicine, Gian Sagar Medical College and Hospital, Ram Nagar, Patiala, Punjab, India E-mail: jotghuman28@gmail.com
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Kaur A, Kaur A. Coexistence of Usual Interstitial Pneumonia and Small Cell Lung Cancer: A Case Report. J Med Health Sci. 2025;12(2):117-20.
Timeline
Received : April 14, 2025
Accepted : May 30, 2025
Published : December 30, 2025
Abstract
Introduction: The coexistence of usual interstitial pneumonia (UIP) and small
cell lung cancer (SCLC) is uncommon, especially in patients with underlying
connective tissue diseases such as scleroderma.
Methods: We report a case of a 42-year-old female with scleroderma presenting
with persistent cough and dyspnea. Radiological imaging and histopathological
investigations were performed.
Results: High-resolution computed tomography of the chest revealed features
suggestive of UIP with a right lower lobe mass. Fine-needle aspiration cytology
confirmed a diagnosis of small cell carcinoma.
Discussion: This case underscores the importance of high clinical suspicion for
lung malignancy in patients with interstitial lung disease (ILD), particularly when
symptoms change or worsen. Such rare overlap conditions require multidisciplinary
management for optimal patient outcomes. KEYWORDS
References
1. Sgalla G, Biffi A, Richeldi L. Idiopathic pulmonary fibrosis: diagnosis, epidemiology and natural history. Respirology. 2019; 24 (5): 426–437.
2. Hosseini S, Beiranvand S, Sadeghi R, et al. Association between idiopathic pulmonary fibrosis and lung cancer: a systematic review and meta-analysis. Lung Cancer. 2019;134:1–7.
3. Lee K, Lee HY, Kim J, et al. Risk of lung cancer in patients with idiopathic pulmonary fibrosis: a nationwide population-based cohort study. Respiration. 2020;99(4):369–377.
4. Kim HC, Jung CY, Park SY, et al. Clinical characteristics and treatment outcomes of small cell lung cancer in patients with interstitial lung disease. BMC Pulm Med. 2022;22(1):213.
5. Antoniou KM, Margaritopoulos GA, Tomassetti S, et al. Interstitial lung diseases and lung cancer: a complex relationship. Pulm Med. 2020;2020:1–10.
6. Batra N, Sheth R, Kropski JA. Management of lung cancer in patients with fibrotic interstitial lung disease. Curr Opin Pulm Med. 2021; 27(5):354–362.
7. Kato T, Ito S, Tsuzuki T, et al. Small cell lung cancer and interstitial pneumonia associated with anti-transcriptional intermediary factor- 1γ-positive dermatomyositis: a case report. Respirology Case Reports. 2019;7(4):e00412.
8. Kato T, Ito S, Tsuzuki T, Watanabe D, Kubo A, Yamaguchi E. Small cell lung cancer and interstitial pneumonia associated with antitranscriptional intermediary factor-1γ-positive dermatomyositis. Respirol Case Rep. 2019 Mar 12;7(4):e00412. doi: 10.1002/rcr2.412. PMID: 30906559; PMCID: PMC6412960
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
The authors report no conflicts of interest in this work.
About this article
Cite this article
Kaur A, Kaur A. Coexistence of Usual Interstitial Pneumonia and Small Cell Lung Cancer: A Case Report. J Med Health Sci. 2025;12(2):117-20.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.