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Clinicopathological Study of Primary Small Intestine Lymphoma

Komala* , Komala* , Jayalaxmi Y.K.** , Chandrashekar. M***

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Indian Journal of Pathology: Research and Practice 5(2):p 137-142, May-Aug 2016. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.10

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Abstract

 Background and Objectives: Primary malignant tumors of the small intestine are rare and correspond to less than 2% of all tumors of the alimentary tract. Primary nonHodgkin’s lymphoma of small intestine(PLSI) represent 1520% of small bowel malignant tumors. The objective of this study was to ascertain the anatomic distribution, macroscopic type and histological subtypes of PLSI. Materials and Methods: Present study is a prospective descriptive study. During the period 2011-2014 a total of 40 resected specimens of small intestine were received and subjected for detailed morphological examination, out of which 5 cases turned out to be PLSI. These 5 cases were analyzed and classified as per WHO classification. Results: Mean age of presentation was 32 years with male preponderance. Most common presenting complaint was abdominal pain. Most common site was ileum followed by jejunum. Macroscopically they presented diffusely followed by nodular growth. All the cases belonged to Bcell lineage and most common histological subtype was diffuse large B cell lymphoma(DLBCL) followed by MALT lymphoma. Conclusion: Due to its rarity and the lack of characteristic symptoms, PLSI is often not diagnosed until serious complications occur such as intestinal obstruction/ perforation. Hence detailed morphological evaluation is needed to understand the clinicopathological profile of PLSI .

Keywords: Small Intestine; NonHodgkin’s Lymphoma; Intestinal Obstruction.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.5216.10

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