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Indian Journal of Pathology: Research and Practice

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Clinicopathological Evaluation of Various Prognostic Factors in Breast Cancer Along with Hormonal Receptor Status and HER2/neu Expression

Sushma H.M., Assistant Professor, Dept. of Pathology, A.J Institute of Medical Sciences, Mangalore, Karnataka 575004, India. , Shashidhar M.R.* , Sushma H.M.**

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Indian Journal of Pathology: Research and Practice 7(1):p 75-79, January 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7118.13

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Abstract

Introduction: The prevalence of hormone receptor positive breast cancer in Asian countries is found to be lower than the western world where more than 50% of the tumors express hormone receptors. Studies have found consecutive decrease of ER, PR expression as a measure of differentiation of the tumour with low grade having the highest and high grade having the lowest ER/PR expression. Detection of vascular invasion in the primary tumor is a marker of metastatic potential and has prognostic significance, particularly in the lymph node negative group and helps to predict both recurrence and long-term survival. Aims and Objectives: To study the expression of ER, PR and HER2/neu status by immunohistochemistry and correlation of clinicopathological parameters with hormone receptor status and HER2/neu expression. Results: In the present study the age range of the patients was between 35-80 years. Out of 53 cases, majority (72%) of them were invasive ductal carcinoma. Other tumors included medullary carcinoma, lobular carcinoma, metastatic carcinoma and poorly differentiated carcinoma. Nineteen out of 53 tumors (36% of the cases) showed triple negativity and only one tumor showed triple positivity. Of the total cases 32% of the tumors were ER+/PR+, 17 % ER+/PR- and 4% showed ER-/PR+. Conclusion: This study highlights the importance of various prognostic factors and hormone receptor status evaluation that will aid in therapeutic intervention.

Keywords: Breast Cancer; ER; PR; HER2/neu; Lymphovascular. 

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7118.13

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