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Clinical Profile and Management Outcomes of Infectious Keratitis in a Tertiary Eye Care Hospital

M. Meera Alias Devasena, Assitant Professor, Department of Ophthalmology, Sri Ramachandra Medical College & Research Institute, Porur, Chennai, Tamil Nadu 600116, India. , M. Meera Alias Devasena* , Sujatha Mohan** , Mohan Rajan** , Bina John**

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Ophthalmology and Allied Sciences 4(1):p 22-27, Jan-Apr 2018. | DOI: http://dx.doi.org/10.21088/oas.2454.7816.4118.4

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Context: Corneal infection is a leading cause of ocular morbidity and blindness worldwide. Infective corneal ulcers form a major threat to vision and are an important cause of treatable corneal blindness. Settings and Design: Prospective Follow up Study. Aims: To study the Risk factors, etiology, clinical features and to analyse the treatment modalities, response and outcomes in 150 patients of infectious keratitis. Methods and Material: A Prospective study was done among 150 patients of infectious keratitis in a tertiary eye care hospital. History of predisposing factors and symptoms of infectious keratitis were documented. Morphology and characteristics of the ulcer were noted. Fluorescein staining was done in all cases. Patients were started on appropriate antimicrobial therapy based on clinical diagnosis, smear and culture reports. Statistical analysis used: Data entry and analysis were done by SPSS10.0 for windows software. Chi square test was done for risk factors of infectious keratitis. Results: Among the 150 patients, 54% were males and the mean age was 41.3 years. About 54% (81) gave history of trauma. About 44% were diagnosed as fungal keratitis, 40% bacterial keratitis, 12% viral and 4% had acanthamoeba keratitis. Overall 114 corneal ulcers healed well to medical management. Ulcers with trauma and smaller ulcers (< 3 mm) and reported within 7 days of onset of symptoms had better healing rate which was statistically significant (p< 0.013). Conclusions: Bacterial and fungal corneal ulcers are equally prevalent in our population. History of trauma is a significant risk factor. Patients who presented late and fungal etiology had poor prognosis.

Keywords: Infectious Keratitis; Prospective Study; Follow up Study; Hypopyon; Keratoplasty; Corneal Ulcer. 

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DOI: http://dx.doi.org/10.21088/oas.2454.7816.4118.4

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