Home > Journals > Indian Journal of Pathology: Research and Practice

Indian Journal of Pathology: Research and Practice

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Castleman Disease: A Clinicopathological Analysis of 18 Cases

Pavithra P , Namrata Rao1 , Varun Kumar Singh2 , Pavithra P3 , Rashmi Shetty4 , Nikitha Valerina Kairanna5

Author Information

Licence:



Indian Journal of Pathology: Research and Practice 9(2 (Part-1)):p 55-59, May-August 2020. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.9

How Cite This Article:

Namrata Rao, Varun Kumar Singh, Pavithra P, Rashmi Shetty, Nikitha Valerina Kairanna. Castleman Disease: A Clinicopathological Analysis of 18 Cases. Indian J Pathol Res Pract 2020;9(2 Part I):55–59.
 

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Introduction: Castleman disease (CD) is a benign uncommon lymphoproliferative disorder requiring a high index of suspicion. Based on the clinical features and lymph node involvement, they can be categorized into unicentric (UCD) and multicentric (MCD) types. The rarity of this entity and infrequency of diagnosis accounts for the incomplete knowledge of this disease. Materials and Methods: This is a retrospective eight year study conducted in the department of pathology, cases of CD reported on histopathology were retrieved. The age, sex, clinical features site involved and the histopathological type, laboratory findings was noted and analysed. Results: Eighteen cases of CD were reported on histopathology over a period of 8 years. Majority were adults in the age group 30–50 years. There was no sex predilection. Majority of the patients (77.7%) showed features of UCD and four cases showed features of MCD. Most of these patients were asymptomatic and presented with painless lymph node enlargement. Patients with MCD had anaemia, hypoalbuminaemia and raised ESR levels. The
commonest site of involvement was cervical lymph node. Among the cases of CD, 14 cases were of hyaline vascular type, 2 cases were of plasma cell type and 2 cases were of mixed type. Conclusion: CD is a rare entity with a wide spectrum of benign and malignant mimics. Since the presentation is non-specific and CD is usually not suspected clinically, histopathology is the gold standard for diagnosis.

Keywords: Castleman; Hyaline-Vascular; Multicentric, Plasma-cell; Unicentric.
 

References

No records found.


About this article

Cite this article

Namrata Rao, Varun Kumar Singh, Pavithra P, Rashmi Shetty, Nikitha Valerina Kairanna. Castleman Disease: A Clinicopathological Analysis of 18 Cases. Indian J Pathol Res Pract 2020;9(2 Part I):55–59.
 

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.9

Keywords


Article Level Metrics

Last Updated

Sunday 12 July 2026, 13:46:35 (IST)

2018

Accesses

3
434
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share