Abstract

Background: Cholelithiasis is a common gastrointestinal disorder influenced by metabolic and endocrine factors. Subclinical hypothyroidism, characterized by elevated TSH levels while FT4 levels remain normal, has been linked to metabolic dysregulation, which may indirectly contribute to gallstone formation. However, the exact association between subclinical hypothyroidism and cholelithiasis is still debated.

Aim: To assess the association between hypothyroidism and gallstone disease in a hospital-based population, and to analyze metabolic variables along with age that may influence this relationship.

Methods: A hospital-based Prospective study was conducted involving 46 patients, 28 with gallstone disease (cases) and 28 without gallstones (controls). Both groups underwent comprehensive clinical evaluation, laboratory testing, imaging, and gallstone analysis, where applicable. Data were analysed using appropriate tests to assess significance.

Results: Hypothyroidism was significantly more prevalent in the case group (46%) than in controls (12%). Cholesterol stones were the most common type, predominantly among hypothyroid patients (92.5%). Female sex and age 25–45 years were the predominant demographic factors. A significant association was found between Hypothyroidism and gallstone disease (p<0.05)

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