Moumita Chatterjee Demonstrator, Department of Anatomy, College of Medicine and JNM Hospital, WBUHS, Kalyani, Nadia, West Bangal, India
Smita Singh Banerjee Associate Professor & Head, Department of Anatomy, College of Medicine and JNM Hospital, WBUHS, Kalyani, Nadia, West Bangal, India
Kaustav Chakraborty Professor and Head, Department of Psychiatry, College of Medicine and JNM Hospital, WBUHS, Kalyani, Nadia, West Bangal, India
Address for correspondence: Moumita Chatterjee, Demonstrator, Department of Anatomy, College of Medicine and JNM Hospital, WBUHS, Kalyani, Nadia, West Bangal, India E-mail: drmou2005@yahoo.co.in
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Moumita Chatterjee, Smita Singh Banerjee, Kaustav Chakraborty. Association between 2d:4d Ratio and Cardiovascular Risk Factors among Medical Students: A Study from Eastern India. Ind Jr Anat. 2025; 14(2): 43-50.
Timeline
Received : June 16, 2025
Accepted : July 21, 2025
Published : August 10, 2025
Abstract
Background: Several risk factors raise the chance of heart disease. A sexually dimorphic biometric marker is the ratio of the second and fourth digits. There have been multiple findings of a relationship between 2D:4D and cardiac disease. The aim of this study was to examine the relationship between cardiovascular risk factors and the 2d:4d ratio among medical students.
Methods: A total of 200 people participated in this cross-sectional study. Medical students had assessments using anthropometric measures, including waist circumference, body weight, hip circumference, height, neck circumference, body fat percentage, and body mass index and the 2d:4d ratio was examined.
Results: The study shows significant demographic differences among participants, with gender, height, weight, BMI, and digit lengths all showing statistical significance (p < 0.05). However, correlations between digit lengths and anthropometric measures such as BMI, waist-to-hip ratio, neck circumference, and triceps skin fold thickness were weak and statistically insignificant. Additionally, no significant correlations were found between 2d:4d lengths and family history of health conditions.
Conclusion: The study found a correlation between demographic and family history indicating that 2d:4d lengths may not be strongly associated with other physical or hereditary factors.
References
1. World Health Organization, The top 10 causes of death, https://www.who.int/ news-room/ fact-sheets/detail/the-top-10-causes-of-death, (2018), Accessed date: 2 April 2020.
2. S. Dimmeler, Cardiovascular disease review series, EMBO molecular medicine 3 (12) (2011) 697 Dec 1.
3. K.M. Colafella, K.M. Denton, Sex-specific differences in hypertension and associated cardiovascular disease, Nat. Rev. Nephrol. 14 (3) (2018) 185 Mar.
4. Al-Asadi J.N. Handgrip strength in medical students: Correlation with body mass index and hand dimensions. Asian J Med Sci. 2018; 9: 21-6.
5. Manning J.T., Bundred P.E. The ratio of 2nd– 4th digit length: a new predictor of disease predisposition?. Med Hypotheses. 2000; 54(5): 855-7.
6. Manning J.T., Scutt D., Wilson J., LewisJones D.I.. The ratio of 2nd–4th digitlength:a predictor of sperm numbers and levels of testosterone, LH and oestrogen. Hum Reprod. 1998; 13: 3000-4.
7. Wu X.L., Yang D.Y., Chai W.H., Jin M.I., Zhou X.C., Peng L., et al. The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population. Int J Med Sci 2013; 10: 1584-8.
8. Yousefi M., Najafi Saleh H., Yaseri M., Jalilzadeh M., Mohammadi A.A. Association of consumption of excess hard water, body mass index and waist circumference with risk of hypertension in individuals living in hard and soft water areas. Environmental geochemistry and health. 2019 Jun 15; 41: 1213-21.
9. Zhang M., Zhao Y., Wang G., Zhang H., Ren Y., Wang B., Zhang L., Yang X., Han C., Pang C., Yin L. Body mass index and waist circumference combined predicts obesityrelated hypertension better than either alone in a rural Chinese population. Scientific reports. 2016 Aug 22; 6(1): 31935.
10. English K.M., Mandour O., Steeds R.P., Diver M.J., Jones T.H., Channer K.S. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. European heart journal. 2000 Jun 1; 21(11): 890-4.
11. Manning J.T., Bundred P.E.. The ratio of second to fourth digit length and age at first myocardial infarction in men: a link with testosterone? British Journal of Cardiology. 2001; 8: 720-3.
12. Manning J.T., Bundred P.E. The ratio of 2nd to 4th digit length: a new predictor of disease predisposition?. Medical hypotheses. 2000 May 1; 54(5): 855-7.
13. Goldstein J.M., Handa R.J., Tobet S.A. Disruption of fetal hormonal programming (prenatal stress) implicates shared risk for sex differences in depression and cardiovascular disease. Frontiers in neuroendocrinology. 2014 Jan 1; 35(1): 140-58.
14. Wang L., Huo Z., Lu H., Bai C., Li K., Ma W. Digit ratio (2D: 4D) and coronary artery disease in north Chinese women. Early Human Development. 2018 Jan 1; 116: 64-7.
15. Danborno B., Adebisi S.S., Adelaiye A.B., Ojo S.A. Sexual dimorphism and relationship between chest, hip and waist circumference with 2D, 4D and 2D: 4D in Nigerians. The Internet Journal of Biological Anthropology. 2008; 1(2): 1-5.
16. L. Rorholm Pedersen, D. Frestad, M. Mide Michelsen, N. Dam Mygind, H. Rasmusen, H. Elena Suhrs, E. Prescott, Risk factors for myocardial infarction in women and men: a review of the current literature, Curr. Pharm. Des. 22 (25) (2016) 3835–3852 Jul 1.
17. Lu H., Ma Z., Zhao J., Huo Z. Second to fourth digit ratio (2D: 4D) and coronary heart disease. Early human development. 2015 Jul 1; 91(7): 417-20.
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Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
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Conflicts of Interest
The authors report no conflicts of interest in this work.
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Moumita Chatterjee, Smita Singh Banerjee, Kaustav Chakraborty. Association between 2d:4d Ratio and Cardiovascular Risk Factors among Medical Students: A Study from Eastern India. Ind Jr Anat. 2025; 14(2): 43-50.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.