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Indian Journal of Pathology: Research and Practice

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An Immunohistochemical study of Human Papilloma Virus 16 (HPV 16) Expression in the Various Types of Carcinoma Cervix in the Rural Population of Tamilnadu

K.R. Gopalakrishan, Reader, Dept. of Pathology, Rajah Muthaiya Medical College and Hospital, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu 608002, India. , Sylvester N.a , Suban Mohammed Gouseb , K.R. Gopalakrishanc , B. Krishnaswamyd

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Indian Journal of Pathology: Research and Practice 7(3):p 374-376, March 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7318.16

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Abstract

Objective: To Study and observe the immunoexpression of HPV 16 in the various types of carcinoma cervix (Ca Cx) diagnosed in the rural tertiary care hospital in Tamilnadu. Materials & Method: The biopsies 243 cases of carcinoma cervix which was diagnosed in the Division of Pathology for the period of 5 years from January 2011 and December 2016were included for the study. A Total of 43 cases were selected for the immunohistochemical staining (AVIDIN-BIOTIN Method) to find the immunoexpression for HPV 16. A positive immunoexpression of 48.8% was observed for HPV 16 out of which 51.3% are Squamous cell carcinoma and 1 case of Carcinosarcoma of cervix. 6 cases of Adenocarcinoma and 1 case of small cell carcinoma was negative for HPV 16 immunoexpression. Conclusion: Regular and periodic screening for all women above 30 years for cervical cancer and Screening of the most common high-risk HPV types should be done. Cervical cancer awareness programs should have regular follow up.

Keywords: Carcinoma Cervix; High Risk Human Papilloma Virus; HPV 16; Immunoexpression. 

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7318.16

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