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A Study on p53 Expression Patterns and Patients Features: Descriptive Study

Abhilash N.P.* , Abhilash N.P.* , Swayam Prava Pradhan**

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Indian Journal of Pathology: Research and Practice 6(2 (Part-1)):p 255-259, January - June 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6217.15

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Abstract

Introduction: Among the most widely studied tumour suppressor gene are RB & p53 which express PRB retinoblastoma protein & p53 protein respectively. These proteins control cell cycle and are involved in the inhibition of cell proliferation. Mutation of these proteins produce uncontrolled cell proliferation. Methodology: The detailed history including the duration, site, onset, progression, personal habits and duration of those habits like smoking, beetle quid chewing were noted. The clinical diagnosis was recorded. Results: In our study, the most common location was tongue 48% followed by the BUCCAL mucosa of 34% and the least common was the floor of the mouth 6%. It was observed that 59% of the cases in the age group 50-60 year showed suprabasal p53 positivity. Conclusion: No significant association observed between P53 and age,smoking and tobacco use.

Keywords: Oral Lesions; P53; Tobacco.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6217.15

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