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A Study on Histological Classification of Bone Lesions and Features of Malignant Lesions: Descriptive Study

Indudhara P.B.* , Indudhara P.B.* , Pratima S. Patil** , C. Bharat***

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Indian Journal of Pathology: Research and Practice 6(1):p 153-158, January - March 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.26

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Abstract

 Introduction: Osteosarcoma is by far the greatest histological imitator of bone tumours. Both radiologically and histologically, osteosarcoma mimics many other benign and malignant bone lesions.Accurate diagnosis of bone­forming tumors, including correct subclassification of osteogenic sarcoma is critical for determination of appropriate clinical management and prediction of patient outcome. Methodology: All patients with clinical and radiological suspicion of primary and secondary tumours and tumour like lesions of the bone which require biopsy or surgical excision. Biopsy specimens were fixed in 10% formalin for 24 hrs after recording the gross morphological features. Specimen was sampled carefully and bone tissue was cut with hand and electrical saw in to thin slices. Samples containing bone tissue were decalcified before routine processing and paraffin embedding. Results: Among the bone forming tumours, benign tumours were four which constituted one osteoma and two osteoid osteoma and one osteoblastoma.. Malignant bone forming tumours were 3 which constituted conventional osteosarcoma. Among the cartilage forming tumours benign tumours were 11 amongst which osteochondromas were 8, chondromas were 2 and 1 chondroblastomas. The malignant cartilage tumour. was conventionally chondrosarcoma. Marrow origin tumours constituted 2 cases of Ewing’s sarcoma Conclusion: Knowledge of radiological appearances of various bone tumours and tumour like lesions is essential for the pathologist in evaluating the bone tumours.

Keywords: Bone Tumours; Radiology; Osteosarcoma.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.26

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