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A Study of Relationship Between Second Trimester Maternal Serum Beta Human Chorionic Gonadotropin and Hypertensive Disorder of Pregnancy A

Srushti Parmar , Aliya Perveen1 , Srushti Parmar2 , Sharda Goyal3

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Indian Journal of Obstetrics and Gynecology 7(2):p 135-141, April-June 2019. | DOI: http://dx.doi.org/10.21088/ijog.2321.1636.7219.3

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Aliya Perveen, Srushti Parmar, Sharda Goyal. A Study of Relationship Between Second Trimester Maternal Serum Beta Human Chorionic Gonadotropin and Hypertensive Disorder of Pregnancy. Indian J Obstet Gynecol. 2019;7(2):135-141.

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Abstract

Objective: To test the hypothesis that women with high serum beta HCG levels in early second trimester (13-20 weeks) are at higher risk of developing hypertensive disorder of pregnancy and to compare beta HCG levels between normotensive and hypertensive pregnant women. Method: This prospective study was carried out in Department of Obstetrics & Gynaecology, GMCH, Udaipur from January 2017 to January 2018. Estimation of serum beta HCG level was done by enzyme linked fluorescence immunoassay. Followed up in antenatal clinic examined 4 weekly till delivery to note the development of hypertension and its complication. At every visit, blood pressure was recorded and urine was examined for albumin. PIH (pregnancy induced hypertension) included gestational hypertension and preeclampsia. Results: Incidence of PIH was 14% (28 out of 200 patients). Age, parity & socioeconomic status has no relation to development of PIH. There is significant difference in SBP & DBP between normotensive and PIH at the time of delivery (mean difference in SBP was 37.00 mmHg & DBP was 22.4 mmHg). Mean beta HCG in normotensive patients was 27500.10 mIU/ml and 45027.43 mIU/ml in PIH patients. 6.5% patients had beta HCG between 60,000 mIU/ml to 90,000 mIU/ml & among this 84.61% patients developed PIH. 92.50% patient had MOM of beta HCG <2. Among these 9.18% patients developed PIH. 7.50% patients had MOM of beta HCG >2, out of these 73.33% patients developed PIH. Sensitivity of beta HCG as predictor of PIH is 73.33% and specificity is 90.81%. Conclusion: Thus we can say that serum beta HCG level can be used as predictor of PIH as beta HCG is also already done as triple marker test in routine ANC. So it can be used without any extra burden on patient.

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Aliya Perveen, Srushti Parmar, Sharda Goyal. A Study of Relationship Between Second Trimester Maternal Serum Beta Human Chorionic Gonadotropin and Hypertensive Disorder of Pregnancy. Indian J Obstet Gynecol. 2019;7(2):135-141.

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DOI: http://dx.doi.org/10.21088/ijog.2321.1636.7219.3

Keywords

Beta-HCG; Normotensive; PIH; MOM.

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