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A Comparative Study on Pre-emptive Analgesic Effect of IV Paracetamol on Reducing the Use of Opioid in Post-operative Pain Management

Ankur Gandhi , Manmohan Jindal1 , Ankur Gandhi2 , Rishaabh Khandelwal3

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Indian Journal of Anesthesia and Analgesia 6(6):p 2139-2141, November-December 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.41

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Manmohan Jindal, Ankur Gandhi, Rishaabh Khandelwal. A Comparative Study on Pre-emptive Analgesic Effect of IV Paracetamol on Reducing the Use of Opioid in Post-operative Pain Management. Indian J Anesth Analg. 2019;6(6 Part - II): 2139–2141.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Present study was undertaken to see the pre-emptive efficacy of IV paracetamol and reduction in the use of opioid for post-operative pain management. Aim and Objective: To study pre-emptive analgesic effects of 1 gm paracetamol infusion on the total requirement of tramadol in the post-operative period including rescue analgesia. Methods: After ethical approval present study was carried out NSCB Medical College, Jabalpur from October 2009 to September 2010, 90 patients of ASA class I and II between the age group of 20–60 years undergoing elective abdominal surgery were included in the study. Patients were divided into 3 Groups of 30 patients each. Group I was given IV paracetamol infusion 1gm for 15–20 minutes, 30 minutes prior to induction. Group II was IV paracetamol infusion 1 gm for 15–20 minutes prior to skin closure, and Group III received normal saline as placebo. Post-operatively pain (VAS) scores, sedation scores, postoperative tramadol doses, side effects were recorded. Results: Group III, VAS score was significantly higher (p < 0.01) as compare to Group I. Consumption of tramadol in Group III was significantly higher (p < 0.01) compared to Groups I and II. Conclusion: IV paracetamol infusion pre-emptive ensure effective analgesia and decreases tramadol consumption and side effects.

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Manmohan Jindal, Ankur Gandhi, Rishaabh Khandelwal. A Comparative Study on Pre-emptive Analgesic Effect of IV Paracetamol on Reducing the Use of Opioid in Post-operative Pain Management. Indian J Anesth Analg. 2019;6(6 Part - II): 2139–2141.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6619.41

Keywords

IV Paracetamol; Pre-emptive; Tramadol.

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