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A Comparative Study of Fasting Lipid Profile among Women with Normotensive Pregnancy and Hypertensive Disorder of Pregnancy - Prospective Study

, Sneha R. , Harshini V. , Renuka R.

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Indian Journal of Obstetrics and Gynecology 5(3 (Supplement)):p 282-282, Jul-Sep 2017. | DOI:

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Abstract

Background: Pregnancy is well known to be associated with various physiological and metabolic changes including lipid metabolism. Dyslipidemia of pregnancy diagnosed in early pregnancy needs to be followed up to recognise and minimize complications of pregnancy. We conducted a comparative study among third trimester normotensive women and women with hypertensive disorder of pregnancy, measuring their fasting lipid profile. Materials and Methods: The study included 68 pregnant women all in third trimester with hypertensive disorder of pregnancy, and 68 women matched for parity, gestational age and period of gestation during 6 months period of visit to our hospital. Blood sample was collected during fasting and the lipid profile was calculated and compared.

Women with hypertensive disorder of pregnancy were further evaluated for complications of preeclampsia and managed accordingly. A total of 68 women were included in the study. 34 women were hypertensive among whom 14 had preeclampsia, 2 had eclampsia, 8 had oligohydramnios and 14 women had intrauterine growth restriction. Mean triglyceride level among women with hypertensive disorder of pregnancy was found to be Total cholesterol -189 mg/ dl, triglycerides was 210 mg/dl, HDL - 46 mg/dl, LDL - 115 mg/dl , VLDL - 46 mg/dl. The mean fasting lipid profile of normotensive women were Total cholesterol - 124MG/DL, triglcerides -150mg/dl, HDL - 32 mg/dl, LDL- 140 mg/dl, VLDL - 25 mg/ dl.Out of women with hypertensive disorder of pregnancy, 14 women were having severe preeclampsia. Conclusion: There is significant dyslipidemia with raise in triglycerides, HDL, LDL and VLDL found in our study in women with hypertensive disorder of pregnancy in comparison to normotensive pregnant women. As lipid profile can be easily measured in pregnant women, it can be followed up if abnormal so that, complications of pregnancy can be detected early and managed. 

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