Introduction: Plasma transfusion is required to arrest or prevent bleeding, for various
congenital and acquired cases of coagulopathies such as inherited factor deficiencies,
disseminated intravascular coagulation, liver disease, post major trauma, etc. Leukocyte
reduced blood components are indicated to prevent the febrile nonhemolytic transfusion
reactions, Human Leukocyte Antigen (HLA) alloimmunization, transmission of
infections such as cytomegalovirus (CMV), and adverse transfusion reactions due to
storage lesion. In the present study, the effect of plasma filtration on eight coagulation
factors viz. fibrinogen, factors II, V, VII, VIII, IX, X and XI has been studied. Materials
and Methods: The plasma separated from the whole blood donation from each of
25 donors was separated into two aliquots. Group-1 included unfiltered fresh frozen
plasma; group-2 included fresh frozen plasma which was subjected to pre-storage
leukocytereductionbyfiltration.ThelevelsofthecoagulationfactorsFibrinogen,II,V,
VII, VIII, IX, X, XI were estimated in each sample in both the groups. Results: There
was no statistically significant difference in the levels of any of the coagulation factors
included in this study, between the unfiltered and the leukocyte reduced plasma. Group
O positive individuals were found to have higher levels of all the coagulation factors.
Conclusion: Filtration of plasma has no effect on the coagulation factors. This is the
first study where the effect of plasma filtration on eight coagulation factors has been
studied. Blood group O positive individuals were found to have higher levels of all the
eight coagulation factors.
Original Article
English
P. 819-824