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Utility of Cystatin C in Assessing Glomerular Filtatration Rate in Pregnant Women with Preeclampsia

Krishnamurthy U , Krishnamurthy U.1 , Nirmitha Dev M.2 , Meera K.S.3

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RFP Journal of Biochemistry and Biophysics 4(1):p 11-14, January-June 2019. | DOI:

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Krishnamurthy U., Nirmitha Dev M., Meera K.S. Utility of Cystatin C in Assessing Glomerular Filtatration Rate in Pregnant Women with Preeclampsia. RFP Journal of Biochemistry and Biophysics. 2019;4(1):11-14.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background and Objectives: Preeclampsia is a hypertensive disorder of pregnancy associated in the second Trimester of the pregnancy characterized with recent-onset of hypertension and accompanying proteinuria. It affects nearly 5% of all pregnancies, producing substantial maternal and perinatal morbidity and mortality. Kidney injury is one of the complications of preeclampsia complicating the management. Therefore this study intended to find the utility of estimating cystatin C in preeclampsia patients. Material & Methods: 42 preeclampsia patients and equal number of age and gestation age matched normal pregnant women were enrolled for the study. Blood pressures were measured and mean blood pressure values were recorded. Serum cystatin C and creatinine were estimated. Estimated GFR was calculated using MDRD equation. All the observations were tabulated and analysed statistically using software. Results: Cystatin C in pregnant women with preeclampsia and in normal pregnant women was found to be 0.91±0.22 and 0.56±0.16 mg/dl respectively. The difference was statistically significant (p<0.01).Serum cystatin C levels significantly correlated with blood pressure, serum creatinine levels and eGFR values. Conclusion: Thus, cystatin C can be utilised to assess the renal function in preeclampsia complicated pregnancy.

Keywords: cystatin c; Preeclampsia; Pregnancy; Renal marker.

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Krishnamurthy U., Nirmitha Dev M., Meera K.S. Utility of Cystatin C in Assessing Glomerular Filtatration Rate in Pregnant Women with Preeclampsia. RFP Journal of Biochemistry and Biophysics. 2019;4(1):11-14.

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