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To Evaluate the Efficacy of Low Dose Ketamine in Attenuating Haemodynamic Stress Response Induced by Pneumoperitoneum in Laparoscopic Cholecystectomy Under General Anaesthesia: A Prospective Study

Sharma Tejash H., Assistant Professor, Department of Anaesthesiology, Dhiraj Hospital, SBKS Medical Institute & Research Center, Sumandeep Vidyapeeth, Vadodara, Gujarat 391760, India. , Patel Jatin B.1 , Sharma Tejash H.2 , Sumit Kumar3 , Chhaya Akhilesh M.4

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Indian Journal of Anesthesia and Analgesia 5(5):p 800-804, May 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5518.17

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Abstract

 

Background: Pneumoperitoneum required for laparoscopy causes cardiovascular and pulmonary stress responses. Various pharmacological interventions have been used to attenuate those  sympathetic  response. N-methyl-D-aspartate(NMDA) receptor antagonists like ketamine have received great attention. We used low dose of ketamine 0.3mg/kg for attenuation of pressor response. 

Method: Patients scheduled for laparoscopic cholecystectomy were divided in group K (ketamine0.3 mg/kg)and group N(normal saline).Ten minutes before creation of pneumoperitoneum, the (group K) received ketamine 0.3 mg/kg diluted in normal saline intravenously whereas group N received same amount of normal saline. Hemodynamicparameters were monitored and results observed. 

Results: Heart Rate,Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial Pressure were significantly attenuated in group K (p<0.001) as compared to group N. 

Conclusion: Low dose ketamine attenuates hemodynamic response in pneumoperitonium in laparoscopic cholecystectomy.
 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5518.17

Keywords

Laparoscopic Cholecystectomy; Ketamine; Hemodynamic Response.

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