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To Compare the Efficacy of Midazolam and Triclofos as Oral Premedicant in Paediatric Patients

Pooja A Shah , Anubhav Sardana1 , Pooja A Shah2 , Malini Mehta3

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Indian Journal of Anesthesia and Analgesia 6(2):p 543-546, MARCH-APRIL 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.27

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Anubhav Sardana, Pooja A Shah, Malini Mehta. To Compare the Efficacy of Midazolam and Triclofos as Oral Premedicant in Paediatric Patients. Indian J Anesth Analg. 2019;6(2):543-546.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Context: The primary goals of premedication in children are to facilitate a smooth separation from the parents and to ease the induction of anesthesia. Aims: To compare the efficacy of midazolam and triclofos when given orally as premedicants in children. Material and methods: 50 patients aged 2-6 years of ASA I & II were divided randomly into two groups equally. Group M received syrup midazolam, 0.5 mg kg-1 and group T received syrup triclofos 75 mg kg-1, orally as premedication. Level of sedation and behavior [1,3] at the time of separation from parents and during mask acceptance [1,3]. Statistical analysis: Unpaired t-test was used for statistical analysis. p-value <0.05 is significant. Results: In group-M 56% and 40% patients while in group-T 24% and 8% patients achieved a sedation score of 4 and 5 respectively (p<0.05). In group-T 64% and 24% while in group-M 8% and 12% patients achieved a behavior score of 1 and 2 respectively at the time of separation from parents (p<0.05). In group-M 68% and in group-T 24% patients achieved a mask acceptance score of 4 (p<0.05). Conclusion: Oral midazolam 0.5 mg kg-1 was better in terms of level of sedation and behavior at the time of mask acceptance whereas, triclofos 75 mg kg-1 was better in terms of behavior at the time of separation from parents in paediatric age group 2 to 6 years. Hence, midazolam was found to be superior to triclofos.

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Anubhav Sardana, Pooja A Shah, Malini Mehta. To Compare the Efficacy of Midazolam and Triclofos as Oral Premedicant in Paediatric Patients. Indian J Anesth Analg. 2019;6(2):543-546.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.27

Keywords

Paediatric; Midazolam; Triclofos; Sedation; Behaviour score.

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