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The Role of Complement Factors in Neurodegeneration, Neuroinflammation and Neuroprotection: Friend or Foe?

Kumar Senthil P. , Kumar Senthil P. , Adhikari Prabha , Jaganathan

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Indian Journal of Genetics and Molecular Research 2(1):p 29-31, January - June 2013. | DOI:

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Abstract

Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b- 9 membrane attack complex. The complement (C) system has been implicated as a factor in the causation or propagation of tissue injury in central and peripheral nervous system disorders. Complement factors play a predominant role in nerve injury, inflammation and repair, thus playing part in neurodegeneration, neuroinflammation and neuroprotection. 

Keywords: Immunology; Neuroimmunology; Immunogenetics; Genetic neurology; Complement system. 

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