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The Effectiveness of Ondansetron versus Tramadol as Pretreatment in Alleviating Propofol Injection Pain: A Comparative Study

Murali Manoj M., Assistant Professor, KarpagaVinayaga Institute of Medical Sciences & Reasearch Centre, Chinnakolambakkam, Madhurantagam, Kanchipuram District, Tamil Nadu 603308, India. , Mu. Raajaram1 , Murali Manoj M.2

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Indian Journal of Anesthesia and Analgesia 5(9):p 1517-1521, September 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5918.14

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Abstract

Introduction: Propofol is widely used for induction of anesthesia, although the pain during its injection remains a concern for all anesthesiologists. A number of techniques have been adopted to minimize propofol-induced pain. Various 5-hydroxytryptamine- 3 antagonists have shown to reduce propofol-induced pain. Hence, this placebo-controlled study was conducted to compare the efficacy of ondansetron, ramosetron, and lignocaine in terms of attenuation of propofol-induced pain during induction of anesthesia.

Aim of the Study: To assess the effectiveness of ondansetron and tramadol as pre-treatment in alleviating propofol injection pain.

Materials and Methods: 36 patients were randomly allocated into two groups. Group 1 who received up to 2 mL pretreatment with 50 mg tramadol with 1 ml NS while group 2 cases who received 2 mL pretreatment 4 mg ondansetron. The drug is injected into the largest vein on the dorsum of the hand by means of a 20 gauge cannula and the tourniquet being closed to the arm above the cannula and inflated upto 70 mmHg. The tourniquet is deflated after 20 seconds and propofol 2mg/kg injected over 10 seconds and assessment for pain was made.

Results: Tramadol and ondansetron both reduced the incidence and severity of propofol injection pain but pain reduction with ondansetron was significant compared to tramadol (p=0.0402). Significantly 14 patients in the ondansetron group felt no pain when compared to only 8 patients in the tramadol group.

Conclusion: In addition,ondansetron had the additional benefit as it controlled postoperative nausea and vomiting.

 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5918.14

Keywords

Ondansetron; Tramadol; Propofol; Pain; Intravenous Injection.

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