Home > Journals > Indian Journal of Anesthesia and Analgesia

Indian Journal of Anesthesia and Analgesia

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

The Comparative Study of the Efficacy of Palanosetron, Ondansetron and Metoclopramide in the Control of Post-Operative Nausea and Vomitting (PONV)

Deepa T., 11262, 2nd phase, vijayanagar 4th stage Mysore – 570018, Karnataka , Deepa T

Author Information

Licence:



Indian Journal of Anesthesia and Analgesia 4(2):p 427-434, April - June 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.11

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background and Aims: PostOperative Nausea and Vomitting (PONV) Continues to be a highly undesirable outcome of anaesthesia and SX. We compared the efficacy of Palanosetron, Ondansetron an Metoclopramide in the control of PONV. Methods: A total of 60 Patients were randomly allocated to three groups, Group (P): received intravenous Palanosetron 0.25mg, Group (O): received intravenou Ondansetron 4mg, Group (M): received intravenous Metoclopramide 10mg. Incidents of Early (0- 2 Hours) and Late Post-Operative (2- 24 hours) Nausea and Vomiting were assessed. Statistical analysis were performed using Chi- square and Fisher ‘f’ probability test. Results: Incidence of Early Post operative nausea (0-2 hours) in Group (P) was 0% (0/20) Compared to Group (O) and Group (M) which were 5% (1/ 20) and 0% (0/20) respectively. Incidence of late post-operative (2 -24 hours) Nausea in Group (P) was 5% (1/20), Group (O) was 20% (4/20) and Group (M) 10% (2/20) respectively. There is no significant difference in the anti nausea efficacy of Palanosetron compared to ondansetron and metoclopramide. The incidence of early post-operative (0-2  hours) vomiting in Group (P) was 0% (0/20), Group (O) 10% (2/20) and Group (M) 5% (1/ 20). Incidence of Post operative (2-24 hours) vomiting in group (P) 5%(1/20), Group (O) 15 (3/20), Group (M) 15% (3/20). Comparing overall incidence of vomiting showed that the antiemetic efficacy of Palanosetron is the same as Ondansetron and Metoclopramide for Post Operative emisis Conclusion: Prophylactic administration of Palonosetron, Ondansetron and Metoclopramide for PONV, there was no significant difference in the anti-nausea and anti-emetic efficacy of Palonosetron compared to Ondrasetron and Metoclopramide. The magnitude of effect against PONV appears to be similar to that of other established drugs.

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.11

Keywords

Anti-Nausea; Anti-Emetic; PONV; 5HT3 Antagonists; Palanosetron; Metaclopramide

Article Level Metrics

Last Updated

Saturday 07 February 2026, 21:13:34 (IST)

1189

Accesses

0
194
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share