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Synthesis and Insilico Characterization of Some Novel 3, 4 -Dihydropyrimidin -2-(1h)-Thione Derivatives

B. Satya Sree , B Satya Sree , A Lakshmana Rao , B Smiley , BC Lakshmanjee , G Rajesh , K Bhargavi

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Journal of Pharmaceutical and Medicinal Chemistry 6(1):p 9-13, January-June 2020. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6120.2

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B Satya Sree, A Lakshmana Rao, B Smiley et al. Synthesis and Insilico Characterization of Some Novel 3, 4-Dihydropyrimidin-2- (1h)-Thione Derivatives J Pharmaceut Med Chem. 2020;6(1):9–13.
 

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Abstract

Various novel 3,4-dihydropyrimidin-2-(1H)-thione derivatives were prepared by using substituted benzaldehydes, ethylacetoacetate and thiourea in the presence of ammonium molybdate and acetic acid at a temperature of 80-90°C to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and for all the titled compounds physical data like LogP values and biological properties were predicted by using molinspiration soft ware.

Keywords: Substituted benzaldehydes, ethylacetoacetate, thiourea, ammonium molybdate and acetic acid.
 

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B Satya Sree, A Lakshmana Rao, B Smiley et al. Synthesis and Insilico Characterization of Some Novel 3, 4-Dihydropyrimidin-2- (1h)-Thione Derivatives J Pharmaceut Med Chem. 2020;6(1):9–13.
 

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DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6120.2

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