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Study of Inflammatory Markers and Oxidative Stress in Critically ill Patients with Sepsis

Badade ZG , Badade ZG 1 , Kavita More 2 , Jadhav TS 3 , Vyas NL 4

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Indian Journal of Genetics and Molecular Research 9(1):p 9-14, Jaunary–June 2020. | DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.9120.1

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Badade ZG, Kavita More, Jadhav TS, Vyas NL Study of Inflammatory Markers and Oxidative Stress in Critically ill Patients with Sepsis. Indian J Genet Mol Res. 2020;9(1):9–14
 

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Introduction:  Sepsis is the systemic inflammatory response to
infection and remains primary cause of death from infection. Inflammatory markers and oxidative stress has a main role in the pathophysiology of sepsis.

Aims and objectives:  The present study aimed to assess oxidative stress markers (MDA, NO, Vitamin C, SOD, CAT), pro inflammatory markers (IL-6 & IL-8 and CRP) and anti-inflammatory marker (IL-10) in septic patients.

Methodology:  The study included 100 subjects which were divided into two groups. Group 1 (n=60) included ICU patients diagnosed with sepsis. Group 2 (n= 40) Healthy volunteers. Blood Samples were collected from healthy individuals and from septic patients. The oxidative stress markers (MDA, NO, SOD, CAT and Vitamin C levels were measured by spectrophotometer. IL-6, IL-8 were estimated by ELISA and CRP by Quantitative Turbidimetric Latex Assay Method.

Results: The mean serum levels of pro inflammatory cytokines (IL-6, IL-8, CRP) and anti-inflammatory IL- 10 septic patients were highly significantly increased
in septic patients as compared to control subjects. We found mean serum oxidative stress markers (MDA, NO, SOD and CAT) levels were significantly increased in septic patients as compared to control subjects. Mean serum Vitamin C levels were significantly decreased in septic patients as compared to control subjects (p<0.05)

Conclusion: Our study suggests infection and inflammation in septic patients leads to the production of pro inflammatory cytokines, ROS and RNS. This lead to imbalance in the inflammatory network and initiates oxidative stress induced lipid peroxidation of membrane lipids, which is mainly responsible for cellular or organs injury that’s confirmed by elevated
levels of SOD and CAT. Therefore these pro and antiinflammatory and oxidative stress markers are definitely used as a marker for SIRS and to assess progression and severity of the sepsis.


 

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Cite this article

Badade ZG, Kavita More, Jadhav TS, Vyas NL Study of Inflammatory Markers and Oxidative Stress in Critically ill Patients with Sepsis. Indian J Genet Mol Res. 2020;9(1):9–14
 

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DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.9120.1

Keywords

Sepsis; Oxidative stress; Inflammatory markers.

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