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RFP Journal of Biochemistry and Biophysics

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Study of Hormone and Lipid Profile in Polycystic Ovarian Syndrome Women between the Age 18 to 30 Years

Ramchandra K. Padalkar, Professor and HOD, Dept. of Biochemistry, PDVVPF’s Medical College Ahmednagar, Maharashtra 414111, India. , Ramchandra K. Padalkar1 , Sangita M. Patil1 , Dhananjay V. Andure1 , Sonali S. Bhagat1 , Anita M. Raut1

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RFP Journal of Biochemistry and Biophysics 2(1):p 11-15, January - June 2017. | DOI:

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Abstract

Background: Polycystic Ovarian Sydrome (PCOS) is an intense problem which manifiests later as infertility, obesity, insulin resistance, dyslipidemia, endothelial dysfunction & overt diabetes mellitus. PCOS is often associated with abnormalities of other endocrine glands. The study was undertaken to assess hormone levels and lipid profile in polycystic ovarian disease patients and compare it with age & gender matched healthy females. Material and Method: Total 90subjects were enrolled in the present study, out of these 45 were PCOS patients between age group 18 to 30 years, 45 healthy age & sex matched individuals without any evidence of PCOS as per clinical examination was taken as control subjects. Serum Low density lipoprotein – cholesterol (LDLC), High density lipoprotein cholesterol(HDLC) Total cholesterol, Triglycerides (TG), Thyroid stimulating hormone, Total T3 &T4 levels were determined. Results: The results of present study showsthat, women with PCOS have altered lipid & hormone profiles. In current study serum total cholesterol & LDL C were higher while HDLcholesterol was lower as compared with healthy women (p<0.01) The TSH levels were significantly (p<0.001) increased in PCOS patients compared with healthy controls while total T3 & total T4 levels were normal in both groups. Conclusion: In present study, polycystic ovarian patients had subclinical hypothyroidism & this is may be due to unopposed esterogen which stimulates autoimmune reaction like generation of Thyroid peroxidase antibodies. So Analysis of thyroid hormone profile may help in proper treatment. As lipid parameters were associated with the presence of PCOS which mayused for assessment of cardiovascular risk in women with PCOS

Keywords: Polycystic Ovarian Syndrome; Thyroid Hormone; Lipid Profile. 

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