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Study Comparing the Effects of Fentanyl and Dexmedetomidine for Attenuation of the Haemodynamic Response During Endotrcheal Extubation in Patients Undergoing Elective Surgeries

Pasham Abbaiah , Rontala Saraiah1 , Pasham Abbaiah2

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Indian Journal of Anesthesia and Analgesia 7(3):p 679-687, May-June 2020. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.4

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Rontala Saraiah, Pasham Abbaiah. Study Comparing the Effects of Fentanyl and Dexmedetomidine for Attenuation of the
Haemodynamic Response During Endotrcheal Extubation in Patients Undergoing Elective Surgeries. Indian J Anesth Analg.
2020;7(3):679-687.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

 

Introduction: Tracheal extubation is almost always associated with hemodynamic changes due to reflex sympathetic discharge caused by epipharyngeal and laryngo-pharyngeal stimulation. This increase in
sympatho–adrenal activity may result in hypertension, tachycardia and arrhythmias.

Aims: The purpose of the study is to compare the effect of intravenous Fentanyl 1μg/kg with dexmedetomidine 0.7μg/kg on the hemodynamic and recovery responses during extubation.

Materials and methods: Prospective, randomized, double blind, controlled study was conducted in 60 patients of either sex between 20 and 50 yrs of age belonging to ASA-I and II, undergoing general procedures and urological procedures were selected for the
study.

Results: The heart rate increased in both the groups during extubation but the increase was more in Group-F patients. The MAP increased for the initial 1min after drug administration in Group-D. However,
dexmedetomidine attenuated the increase in blood pressure to a greater degree than lignocaine. The airway response (coughing) was better attenuated in Group-D than Group-F. The patients in Group-D were drowsy but responding to verbal commands when compared to Group-F.The incidence of bradycardia and hypotension though minimally present in Group-D, which was easily managed.

Conclusion: Compared to Fentanyl 1μg/ kg, dexmedetomidine 0.7μg/kg administered I.V. before extubation attenuates airway and hemodynamic reflexes to a greater extent allowing smooth and easy tracheal extubation, thereby providing comfortable recovery

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Rontala Saraiah, Pasham Abbaiah. Study Comparing the Effects of Fentanyl and Dexmedetomidine for Attenuation of the
Haemodynamic Response During Endotrcheal Extubation in Patients Undergoing Elective Surgeries. Indian J Anesth Analg.
2020;7(3):679-687.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.7320.4

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