Home > Journals > Journal of Pharmaceutical and Medicinal Chemistry

Journal of Pharmaceutical and Medicinal Chemistry

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Structural Studies and Biological Activity of Thiobarbituric Acid Complexes

Reham O. El-Zawawy, Chemistry Department, Faculty of Science, Damanhour University, Damanhour, Egypt , Mamdouh S. Masoud1 , Ismail M. Abed2 , Reham O. El-Zawawy3

Author Information

Licence:



Journal of Pharmaceutical and Medicinal Chemistry 4(2):p 55-65, Jul-Dec 2018. | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4218.3

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Twelve complexes derived from thiobarbituric acid with Cu, Zn, Co, Fe, Cd and Ni have been prepared and analyzed in the mole ratios 1:1,1:2, 1:3 and 1:4 (M : L). They were characterized by elemental analysis, UV-Vis, IR, 1H-NMR, ESR for Copper complexes, Magnetic Susceptibility and Thermal Analysis (TGA, DTA). The biological activities of thiobarbituric acid and its complexes which are tested against staphylococcus aureus (Gram positive) bacteria, Esherichia coli (Gram negative) bacteria and Candida albicans fungi. The results showed that some of the tested compounds have a well considerable activity against the tested microorganisms. The data of MIC showed that Cu (II) complexes were the most effective antibacterial and antifungal agents compared to the other complexes. 

Keyword: Thiobarbituric acid; Biological Activity; ESR; Magnetic Susceptibility; IR; MIC. 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.4218.3

Keywords


Article Level Metrics

Last Updated

Monday 07 September 2026, 23:09:41 (IST)

1018

Accesses

2
100
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share