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Pediatric Education and Research 2(1):p 15-17, January - March 2014. | DOI:
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Screening of Neonates for Glucose-6 -Phosphate Dehydrogenase Deficiency
Naik Raviraj R. , Naik Raviraj R. , Chandel Rittu C. , Abichandani Leel G.
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Pediatric Education and Research 2(1):p 15-17, January - March 2014. | DOI:
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Abstract
Context: Glucose – 6 – phosphate dehydrogenase (G-6-PD) is an enzyme that participates in the first step of Hexose monophosphate pathway of glucose metabolism. Deficiency of this enzyme is most common genetic disorder in India. Its deficiency causes hemolysis which eventually lead to acute hemolytic anemia and neonatal jaundice. The hemolysis in these deficient patients are triggered by bacterial, viral infections, drugs like aspirin and chloroquine, foods like fava beans Period from after birth to first 4 weeks is the neonatal period and the child is called a neonate.There is no cure for G-6-PD.Early detection and prevention of hemolytic episodes by avoiding the triggers is the only cure for this deficiency. Aim: To screen the neonates for glucose -6-Phosphate dehydrogenase deficiency so as to prevent the morbidity and mortality occurring due to this deficiency. Material and Methods: Hundred neonatal blood sample were obtained from the Labour room, of the Hospital.The samples were analysed by Dye Decolourization method. Statistical Analysis: Pie Diagram is used to show the number of affected neonates found in screening. Results: Of the hundred samples, one was found to be G-6- PD deficient and two were found to be G-6-PD deficiency carriers. Conclusion: G-6-PD deficiency testing should be done as a screening procedure in the whole country as early diagnosis and prevention is the only way of treating this deficiency disorder and avoiding its complications.
Keywords: Glucose – 6 – phosphate dehydrogenase (G-6-PD); Deficiency; Neonate; Hemolysis; Screening.
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