Home > Journals > Journal of Hospital Administration

Journal of Hospital Administration

Submit your article Read this Journals View all journals
Full Text (PDF)
Case Report

Role of Fibrinogen Concentrate and Its Effect on Blood Loss in on Pump Cardiac Surgeries: A Case Series

Samiksha Subhash Waghchaure, Manjula Sarkar

Author Information

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Journal of Hospital Administration 9(2):p 87-90, July-December 2025. | DOI: https://doi.org/10.21088/jha.2582-3566.9225.5

How Cite This Article:

Manjula Sarkar, Samiksha Subhash Waghchaure. Role of Fibrinogen Concentrate and Its Effect on Blood Loss in on Pump Cardiac Surgeries: A Case Series. RFP Journal of Hospital Administration; 2025; 9(2): 87-90

Timeline

Received : October 14, 2025         Accepted : December 02, 2025          Published : December 25, 2025

Abstract

Background: Excessive bleeding is a common complication of cardiac surgery requiring cardiopulmonary bypass (CPB), often leading to increased transfusion requirements and postoperative morbidity. Fibrinogen plays a central role in coagulation, and Human Fibrinogen Concentrate (HFC) offers a targeted method to restore clot firmness Objective: To evaluate the effect of HFC administration on perioperative blood loss in patients undergoing cardiac surgery with CPB Methods: A case series of 12 patients undergoing cardiac surgery was analyzed. Patients were divided into two groups: Group A (n=6) received fibrinogen concentrate (40 mg/ kg) after CPB and before protamine administration, while Group B (n=6) did not. Blood loss and transfusion requirements were compared Results: Mean blood loss in patients receiving fibrinogen concentrate (Group A) was significantly reduced compared to controls (Group B). Statistical analysis demonstrated a highly significant difference (p < 0.001). Patients in Group A also required fewer transfusions of blood and blood products Conclusion: Administration of fibrinogen concentrate in cardiac surgery patients on CPB effectively reduced perioperative bleeding and the need for transfusion. This supports its use as a safe and effective adjunct in perioperative hemostatic management.

References

  • 1.   Sadeghi M, Atefyekta R, Azimaraghi O, Marashi SM, Aghajani Y, Ghadimi F, et al. A randomized, double blind trial of prophylactic fibrinogen to reduce bleeding in cardiac surgery. Braz J Anesthesiol. 2014;64(4):253–7. doi:10.1016/j.bjane.2013.10.010
  • 2.   Zacharias A, Habib RH. Factors predisposing to median sternotomy complications: deep vs superficial infection. Chest. 1996;110(5):1173–8. doi:10.1378/chest.110.5.1173.
  • 3.   Unsworth-White MJ, Herriot A, Valencia O, Poloniecki J, Smith EE, Murday AJ, et al. Resternotomy for bleeding after cardiac operation: A marker for increased morbidity and mortality. Ann Thorac Surg. 1995;59(3): 664–7. doi:10.1016/0003-4975(94)00995-3.
  • 4.   Paparella D, Brister SJ, Buchanan MR. Coagulation disorders of cardiopulmonary bypass: A review. Intensive Care Med. 2004;30(10):1873–81. doi: 10.1007/s00134-004-2388-0.
  • 5.   Wahba A, Rothe G, Lodes H, Barlage S, Schmitz G, Birnbaum DE. Predictors of blood loss after coronary artery bypass grafting. J Cardiothorac Vasc Anesth. 1997;11(7):824–7.
  • 6.   Furie B, Furie BC. Mechanisms of thrombus formation. N Engl J Med. 2008;359(9):938–49. doi:10.1056/NEJMra0801082.
  • 7.   De Lorenzo C, Calatzis A, Welsch U, Heindl B. Fibrinogen concentrate reverses dilutional coagulopathy induced in vitro by saline but not by hydroxyethyl starch 6%. Anesth Analg. 2006;102(4):1194–200. doi:10.1213/01. ane.0000200297.98089.ce.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.

About this article

Cite this article

Manjula Sarkar, Samiksha Subhash Waghchaure. Role of Fibrinogen Concentrate and Its Effect on Blood Loss in on Pump Cardiac Surgeries: A Case Series. RFP Journal of Hospital Administration; 2025; 9(2): 87-90

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Received Accepted Published
October 14, 2025 December 02, 2025 December 25, 2025
DOI: https://doi.org/10.21088/jha.2582-3566.9225.5

Keywords

Fibrinogen ConcentrateCardiac SurgeryCardiopulmonary BypassBleeding ManagementBlood LossHemostasis

Article Level Metrics

Last Updated

Thursday 08 October 2026, 04:17:07 (IST)

1247

Accesses

6
190
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received October 14, 2025
Accepted December 02, 2025
Published December 25, 2025

licence

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share