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Randomised Clinical Trial on Effect of Adding Magnesium Sulphate with 0.75% Ropivacaine and Dexmedetomidine with 0.75% Ropivacaine in Patients Undergoing Elective Laparotomy in a tertiary care hospital

Murali Manoj , P. Manohar1 , M. Murali Manoj2

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Indian Journal of Anesthesia and Analgesia 6(2):p 509-514, MARCH-APRIL 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.23

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P. Manohar, M. Murali Manoj. Randomised Clinical Trial on Effect of Adding Magnesium Sulphate with 0.75% Ropivacaine and Dexmedetomidine with 0.75% Ropivacaine in Patients Undergoing Elective Laparotomy in a tertiary care hospital. Indian J Anesth Analg. 2019;6(2):509-514.
 

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: Laparotomies requires a good amount of pain relief postoperatively to avoid delay in recovery and reduce the duration of stay in the hospital. Among multiple modalities of pain relief postoperative wound infiltration is simple, easy to administer and it has minimal systemic side effects. In our study, we are going to compare the efficacy of 5% magnesium sulfate with 1.5 µg/kg dexmedetomidine along with 0.75% ropivacaine. It's the effect on the postoperative opioid requirement. Material and Methods: 60 ASA I and II patients who are posted for elective laparotomies were randomized to receive one of two treatments: Group RM: 30 ml of drug (0.75% Ropivacaine 3 mg/kg with 5% Magnesium sulfate). Group RD: 30 ml of drug (0.75% Ropivacaine 3 mg/kg with 1.5 µg/kg Dexmedetomidine). Postoperative VAS scoring, time for first rescue analgesia, total tramadol requirement in first 24 hours, patient satisfaction and complications like nausea, vomiting, bradycardia, hypotension, respiratory depression were noted and expressed as mean and standard deviation. Data analyzed with SPSS software version 16.0. p < 0.05 considered statistically significant. Results: Time for first rescue analgesia was earlier in the RM group when compared to the RD group (p>0.05). the total dose of tramadol requirement significantly less with RD group 421.02 ± 21.2 when compared to RM group 221.08 ± 12.6 (p<0.005), sedation score (Grade 2 level sedation) and patient satisfaction scores were significantly higher with RD group (p<0.05). Conclusion: Results of our study concludes that 0.75% Ropivacaine with 1.5 µg/kg Dexmedetomidine provides better postoperative analgesia by reducing the dose of tramadol requirement with good sedation and excellent patient satisfaction than 0.75% Ropivacaine with 5% Magnesium Sulphate in patients undergoing elective laparotomies.

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P. Manohar, M. Murali Manoj. Randomised Clinical Trial on Effect of Adding Magnesium Sulphate with 0.75% Ropivacaine and Dexmedetomidine with 0.75% Ropivacaine in Patients Undergoing Elective Laparotomy in a tertiary care hospital. Indian J Anesth Analg. 2019;6(2):509-514.
 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6219.23

Keywords

Ropivacaine; Dexmedetomidine; Elective Laparotomy

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