Home > Journals > Indian Journal of Cancer Education and Research

Indian Journal of Cancer Education and Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Prospective Analysis of Dosimetric Parameters and Toxicity Outcomes in Cervical Cancer Patients undergoing Concurrent Chemoradiation with Bonemarrow Sparing IMRT Using Spect Correlation

: Nindra Armugram, Assistant Professor, Department of Radiotherapy, MNJIO & RCC, Osmania Medical College, Hyderabad, Telangana 500095, India. , Nindra Armugram* , A.R. Sharath Chandran**

Author Information

Licence:



Indian Journal of Cancer Education and Research 6(1):p 18-30, January-June 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.6118.2

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

 

 

 

Aim: Study was to evaluate feasibility and benefits of Bone Marrow Sparing IMRT over Standard IMRT. 

Materials and Methods: Cervical cancer patients undergoing Concurrent Chemo Radiation and brachytherapy and evaluated for haematological, gastrointestinal and genitourinary toxicity at weekly intervals were included in study. Results: Dose constraints to bone marrow of V10<90% and V20<75% were achieved in all patients. Significant reduction in bone marrow V10 and V20 is possible using bone marrow sparing as compared to standard IMRT (V10 87.15% vs. 93.7% and V20 73.55% vs. 83.15%). Bone marrow sparing can be achieved without compromise to target coverage and without increased dose to OAR’s which include bowel, rectum and bladder. Bone marrow sparing appears to show significant reduction in haematological toxicity in terms of fall in haemoglobin, haemoglobin nadir and grade 2 and worse anaemia. Bone marrow sparing appears to show a trend towards reduced haematological toxicity in terms of fall in WBC count, leukocyte nadir and grade 2 and worse leukopenia. 

Conclusions: SPECT­BM imaging may be added to the ever growing list of functional imaging techniques that may play a role in IMRT planning. Bone marrow sparing approach may also benefit patient s with anal and rectal cancers. 

Keywords: Intensity Modulated Radiation,Therapy (IMRT); Single­Photon Emission Computed, Tomography (SPECT) bone Marrow (BM) Imaging; Cervical Cancer


 

 

 

 

 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.6118.2

Keywords


Article Level Metrics

Last Updated

Friday 31 July 2026, 15:27:26 (IST)

1318

Accesses

11
266
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share