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Case Report

Primary Breast Lymphoma in A 25-Year-Old Young Woman: A Case Report and Review of Literature

V S Haritha null, Shyamji Rawat1 null, V S Haritha2 null

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Indian Journal of Cancer Education and Research 10(2):p 103-106, july-december 2022. | DOI: https://doi.org/10.21088/ijcer.2321.9815.10222.7

How Cite This Article:

How to cite this article: Shyamji Rawat, V S Haritha/Primary Breast Lymphoma in A 25-Year-Old Young Woman: A Case Report and Review of Literature/Indian J Canc Educ Res 2022;10(2):103-106.


Timeline

Received : November 27, 2022         Accepted : December 11, 2022          Published : December 30, 2022

Abstract

Primary breast lymphoma is a rare entity comprising 0.4-0.5% of all breast neoplasms. Diffuse large B-cell 
lymphoma is the most common identifiable type of primary breast lymphoma with the usual presentation being that 
of a painless palpable mass similar to breast carcinoma. A confirmed diagnosis is based on initial biopsy findings or 
post-operative histopathology and immunohistochemistry (IHC) reports. The treatment options vary from surgical 
interventions to chemotherapy and/or radiotherapy. However, there is no uptodate standard treatment guidelines 
present. In view of this rarity, we herein report a case of a 25 year-old young woman who presented with primary 
breast lymphoma of DLBCL variety.


References

  • 1.   Aviv A, Tadmor T, Polliack A. Primary diffuse large B-cell lymphoma of the breast: looking at pathogenesis, clinical issues and therapeutic options. Ann Oncol. 2013; 24:2236–2244.
  • 2.   Surov A, Holzhausen HJ, Wienke A, Schmidt J, Thomssen C, Amold D, Ruschke K, Spielmann RP. Primary and secondary breast lymphoma: prevalence, clinical signs and radiological features. Br J Radiol. 2012;85:e195–e205.
  • 3.   Lokesh KN, Sathyanarayanan V, Lakshmaiah KC, et al. Primary breast diffuse large B cell lymphoma – report of 6 cases from South India with review of literature. Indian J Surg Oncol. 2013;4(4):368–73.
  • 4.   Wiseman C, Liao KT. Primary lymphoma of the breast. Cancer 1972;29:1705–12.
  • 5.   Jabbour G, El-Mabrok G, Al-Thani H, El-Menyar A, Al Hijji I, Napaki S. Primary Breast Lymphoma in a Woman: A Case Report and Review of the Literature. Am J Case Rep. 2016;17:97-103. Published 2016 Feb 19. doi:10.12659/ajcr.896264.
  • 6.   Jeon HJ, Akagi T, Hoshida Y, Hayashi K, Yoshino T, Tanaka T et al. Primary non-Hodgkin lymphoma of the breast. An immunohistochemical study of seven patients and literature review of 152 patients with breast lymphoma in Japan. Cancer 1992;70:2451–9.
  • 7.   Yhim HY, Kang HJ, Choi YH, Kim SJ, Kim WS. Clinical outcomes and prognostic factors in patients with breast diffuse large B cell lymphoma; Consortium for Improving Survival of Lymphoma (CISL) study. BMC Cancer. 2010;10:321. doi: 10.1186/1471-2407-10-321.
  • 8.   Lyou CY, Yang SK, Choe DH, Lee BH, Kim KH. Mammographic and sonographic findings of primary breast lymphoma. Clin Imaging 2007;31:234–8.
  • 9.   Jia Y., Sun C., Liu Z., Wang W., Zhou X. Primary breast diffuse large B-cell lymphoma: a population-based study from 1975 to 2014. Oncotarget. 2018; 9: 3956-3967.
  • 10.   Jennings WC, Baker RS, Murray SS, Howard CA, Parker DE, Peabody LF, et al. Primary
  • 11.   Moura C, Leite MI, Parreira R, Medeiros A. Primary breast lymphoma. J Surg Case Rep. 2020;2020(1):rjz405. Published 2020 Jan 20. doi:10.1093/jscr/rjz405
  • 12.   Fruchart C, Denoux Y, Peny AM. High grade primary breast lymphoma: is it a different clinical entity? Breast Cancer Res Treat 2005;93:191–8.
  • 13.   Zhao YF, Jiao F, Liang HQ, et al. Primary malignant non-Hodgkin’s lymphoma of the breast: A case report. Oncol Lett. 2014;8(6):2597–600.
  • 14.   L. Liberman, C.S. Giess, D.D. Dershaw, D.C. Louie, B.M. Deutch Non-Hodgkin lymphoma of the breast: imaging characteristics and correlation with histopathologic findings ,Radiology, 192 (1994), pp. 157-160.
  • 15.   S.H. Kim, M.P. Ezekiel, R.Y. Kim ,Primary lymphoma of the breast, Am. J. Clin. Oncol., 22 (1999), pp. 381-383.
  • 16.   Veena Gupta, Namita Bhutani, Sunita Singh, Sonia Chhabra, Rajeev Sen,Primary non-Hodgkin's lymphoma of breast – A rare cause of breast lump,Human Pathology: Case Reports,Volume 7,2017,Pages 47-50,ISSN 2214-3300.
  • 17.   Singh NG, Kapila K, Dawar R, Verma K. Fine needle aspiration cytology diagnosis of lymphoproliferative disease of the breast. Acta Cytol. 2003;47(5):739–743. doi: 10.1159/000326598.
  • 18.   Chopra S, Bahl G, Ramadwar M, Ramani S, Nair R, Muckaden MA, et al. Synchronous mucosaassociated lymphoid tissue (MALT) lymphomas involving bilateral orbits and breasts: a rare clinical entity. Leuk Lymphoma. 2005;46(8):1247– 1250. doi: 10.1080/10428190500063203.
  • 19.   Ryan G, Martinelli G, Kuper-Hommel M, et al. Primary diffuse large B-cell lymphoma of the breast: prognostic factors and outcomes of a study by the International Extranodal Lymphoma Study Group. Ann Oncol. 2008;19:233–41.
  • 20.   Uesato M, Miyazawa Y, Gunji Y, et al. Primary non-Hodgkin lymphoma of the breast: report of a case with special reference to 380 cases in the Japanese literature. Breast Cancer. 2005;12:154–58

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

How to cite this article: Shyamji Rawat, V S Haritha/Primary Breast Lymphoma in A 25-Year-Old Young Woman: A Case Report and Review of Literature/Indian J Canc Educ Res 2022;10(2):103-106.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


Received Accepted Published
November 27, 2022 December 11, 2022 December 30, 2022

DOI: https://doi.org/10.21088/ijcer.2321.9815.10222.7

Keywords

Keywords: primary breast neoplasmyoung womanDLBCLimmunohistochemistry.young womanDLBCLimmunohistochemistry.

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Received November 27, 2022
Accepted December 11, 2022
Published December 30, 2022

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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