Abstract

Oral squamous cell carcinoma, commonly referred to as oral cancer, is considered to develop as a result of multi-hit process that involves a number of aberrant genetic events. Determining which event leads to the eventual development of oral cancer can be of a great significance in its prevention and control. p53 a tumor suppressor gene, in its mutated form is believed to exert tumorigenic influences and has been a subject of intensive study over several years in order to understand its role in the process of carcinogenesis.
 

• 1.   Johnson NW. Global Epidemiology. In: Shah JP, Johnson NW, Batsakis JG, editors. Oral Cancer. Martin Dunitz, UK 2003; First ed: 3-32.
• 2.   Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of mouth cancer: A review of global incidence. Oral Diseases 2000; 6: 65-74.
• 3.   Teni T, Pawar S, Sanghvi V, Saranath D. Expression of bcl-2 and bax in chewing tobacco-induced oral cancers and oral lesions from India. Pathol Oncology Res. 2002; 8: 109-14.
• 4.   Lim SC, Zhang S, Ishii G, Endoh Y, Kodama K et al. Predictive markers for late cervical metastasis in stage I and II invasive squamous cell carcinoma of the oral tongue. Clin Cancer Res. 2004; 10: 166-72.
• 5.   Johnson NW, Van der Waal I, Axell T. Oral leukoplakia. Oral Diseases 1997; 3: 47-8.
• 6.   Scully C, Sudbo J, Speight PM. Progress in determining the malignant potential of oral lesions. J Oral Pathol Med. 2003; 32: 251-6.
• 7.   Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell 1990; 6: 759-67.
• 8.   Califano J, Van der Riet P, Westra W, Nawroz H, Clayman G et al. Genetic progression model for head and neck cancer: Implications for field cancerization. Cancer Res. 1996; 56: 2488-92.
• 9.   Nagpal JK, Das BR. Oral cancer: Reviewing the present understanding of its molecular mechanism and exploring the future directions for its effective management. Oral Oncology 2003; 39: 213-21.
• 10.   Macluskey M, Chandrachud LM, Pazouki S, Green M, Chisholm DM et al. Apoptosis, proliferation and angiogenesis in oral tissues: Possible relevance to tumor progression. J Pathol. 2000; 191: 368-75.
• 11.   Braakhuis BJM, Leemans CR, Brakenhoff RH. A genetic progression model of oral cancer: Current evidence and clinical implications. J Oral Pathol Med. 2004; 33: 317-22.
• 12.   Murti PR, Warnakulasuriya KAAS, Johnson NW, Bhonsle RB, Gupta PC et al. p53 expression in oral precancer as a marker for malignant potential. J Oral Pathol Med. 1998: 27: 191-6.
• 13.   Pande P, Soni S, Kaur J, Agarwal S, Mathur M et al. Prognostic factors in betel and tobacco-related oral cancer. Oral Oncology 2002; 38: 491-9.
• 14.   Kushner J, Bradley G, Jordan RCK. Patterns of p53 and Ki-67 protein expression in epithelial dysplasia
• 15.   Piffko J, Bankfalvi A, Ofner D, Joos U, Bocker W, Schmid KW. Immunohistochemical detection of p53 protein in archival tissues from squamous cell carcinoma of the oral cavity using wet autoclave antigen retrieval. J Pathol. 1995; 176: 69-75

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