Mitral Valve Replacement Surgery for a Pregnant Patient with Severe Mitral Stenosis and a Large Left Atrial Clot: A Case Report and Brief Review of Literature
Sambhunath Das Professor, Department of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India
Sumedha Suresh Kumar Senior Resident, Department of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India
Thiruselvan T Senior Resident, Department of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India
Address for correspondence: Sambhunath Das, Professor, Department of Cardiac Anaesthesia and Critical Care, All India Institute of Medical Sciences, New Delhi, India E-mail: sambhunathds833@gmail.com
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Kumar SS, Das S, Thiruselvan T. Mitral Valve Replacement Surgery for a Pregnant Patient with Severe Mitral Stenosis and a Large Left Atrial Clot: A Case Report and Brief Review of Literature. Indian J Cardiovasc Med Surg. 2025;11(2):79-84.
Timeline
Received : August 08, 2025
Accepted : August 29, 2025
Published : August 30, 2025
Abstract
Rheumatic mitral stenosis is the most common cardiac disease complicating pregnancy in India constituting almost 88% of the cardiac diseases in pregnancy. Surgical valve replacement during pregnancy is reserved for those patients in whom percutaneous techniques are not feasible or in whom medical management has failed. Although cardiac surgery during pregnancy is associated with significant maternal and fetal risks, it can be carried out safely by a meticulous plan of anesthesia and making modifications in the initiation and maintenance if cardiopulmonary bypass. In this report, we present the successful perioperative management of a patient posted for mitral valve replacement at 17 weeks of gestation with a huge left atrial clot and a live fetus.
References
1. Bhatla N, Lal S, Behera G, Kriplani A, Mittal S, Agarwal N, et al. Cardiac disease in pregnancy. Int J Gynaecol Obstet. 2003 Aug;82(2):153–9.
2. European Society of Gynecology (ESG), Association for European Paediatric Cardiology (AEPC), German Society for Gender Medicine (DGesGM), Regitz-Zagrosek V, Blomstrom Lundqvist C, Borghi C, et al. ESC Guidelines on the management of cardiovascular diseases during pregnancy: the Task Force on the Management of Cardiovascular Diseases during Pregnancy of the European Society of Cardiology (ESC). Eur Heart J. 2011 Dec;32(24):3147–97.
3. Norrad RS, Salehian O. Management of Severe Mitral Stenosis During Pregnancy. Circulation. 2011;124(24):2756–60.
4. Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J, Blomström-Lundqvist C, Cífková R, De Bonis M, et al. 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018 Sep 7;39(34):3165–241.
5. Chambers CE, Clark SL. Cardiac surgery during pregnancy. Clin Obstet Gynecol. 1994 Jun;37(2):316–23.
6. Parry AJ, Westaby S. Cardiopulmonary bypass during pregnancy. Ann Thorac Surg. 1996 Jun;61(6):1865–9.
7. Weiss BM, von Segesser LK, Alon E, Seifert B, Turina MI. Outcome of cardiovascular surgery and pregnancy: a systematic review of the period 1984-1996. Am J Obstet Gynecol. 1998 Dec;179(6 Pt 1):1643–53.
8. Erdoğan Basri H, Kayalar N, Bozbuğa N, Kutay S, Akbayrak H, Erdem Toker M, et al. Cardiac operations for mitral valve disease during pregnancy. Turk Gogus Kalp Dama. 2006(14):254–9.
9. Champsaur G, Vedrinne C, Martinot S, Tronc F, Robin J, Ninet J, et al. Flow-induced release of endothelium-derived relaxing factor during pulsatile bypass: experimental study in the fetal lamb. J Thorac Cardiovasc Surg. 1997 Nov;114(5):738–44; discussion 744-745.
10. Masada K, Shimamura K, Kuratani T, Sawa Y. Management of foetal circulation by switching to pulsatile perfusion during cardiovascular surgery in pregnancy. Eur J Cardiothorac Surg. 2018 Mar 1;53(3):680–1.
11. Pomini F, Mercogliano D, Cavalletti C, Caruso A, Pomini P. Cardiopulmonary bypass in pregnancy. Ann Thorac Surg. 1996 Jan;61(1):259–68.
12. Kikon M, Dutta Choudhury K, Prakash N, Gupta A, Grover V, Kumar Gupta V. Mitral valve replacement in a young pregnant woman: a case report and review of literature. Res Cardiovasc Med. 2014 May;3(2):e17561.
13. Carlier L, Devroe S, Budts W, Van Calsteren K, Rega F, Van de Velde M, et al. Cardiac interventions in pregnancy and peripartum - a narrative review of the literature. J Cardiothorac Vasc Anesth. 2020 Dec;34(12):3409–19.
14. Grocott HP, Stafford-Smith M, Mora-Mangano CT. Cardiopulmonary Bypass Management and Organ Protection. In: Kaplan’s Essentials of Cardiac Anesthesia [Internet]. Elsevier; 2018 [cited 2025 Jul 27]. p. 608–63. Available from: https://linkinghub.elsevier.com/retrieve/ pii/B9780323497985000255.
Data Sharing Statement
There are no additional data available.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
Information not provide.
Conflicts of Interest
The authors report no conflicts of interest in this work.
About this article
Cite this article
Kumar SS, Das S, Thiruselvan T. Mitral Valve Replacement Surgery for a Pregnant Patient with Severe Mitral Stenosis and a Large Left Atrial Clot: A Case Report and Brief Review of Literature. Indian J Cardiovasc Med Surg. 2025;11(2):79-84.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.