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Microwave Assisted Synthesis and Antimalarial Activity of Coumarin- Pyrazoline Hybrids

Mohemmed Faraz Khan* , Mohemmed Faraz Khan* , Garima Verma* , Wasim Akhter* , Mymoona Akhter* , Mohammad Mumtaz Alam* , Mohammad Shaquiquzzaman*

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Journal of Pharmaceutical and Medicinal Chemistry 2(2):p 137-140, July-December 2016. | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2216.2

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Abstract

 Pyrazline derivatives (3a-3i) were synthesized by using microwave irradiation i.e. by involving green chemistry. These compounds were taken for in vitro antimalarial activity using schizont maturation inhibition assay, using chloroquine as the standard against chloroquine sensitive, 3D7 strain of P. falciparum. Activity of the compounds was reported in terms of IC50 values. Compound 3h with dimethylamino substitution was found to be most active with IC50 value of 13.765 ìg/mL. From the results, it can be easily inferred that the bulky groups favoured antimalarial activity.

Keywords: Pyrazoline; Antimalarial; Microwave.

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DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.2216.2

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