Home > Journals > Journal of Pharmaceutical and Medicinal Chemistry

Journal of Pharmaceutical and Medicinal Chemistry

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Insilico Admet Predictions of Dihydropyrimidinones using Swiss Adme, Pkcsm, Lazar and Protox.

P Soma yasaswi , P Soma yasaswi , P Sai Harshita , Anuradha Bai

Author Information

Licence:



Journal of Pharmaceutical and Medicinal Chemistry 6(1):p 21-26, January-June 2020. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6120.4

How Cite This Article:

P Soma Yasaswi, P SaiHarshita, AnuradhaBai. Insilico Admet Predictions of Dihydropyrimidinones using Swiss Adme, Pkcsm, Lazar and Protox. J Pharmaceut Med Chem. 2020;6(1):21–26.
 

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Drug development and discovery failures are attributed to poor pharmacokinetics, bioavailability, efficacy and toxicity. By monitoring the physicochemical properties of lead compounds, it has become feasible to increase the quality of drug candidates. Toxicity determination of chemicals is crucial to identify their deleterious effects on humans, Animals, plants and the environment. Numerous Insilico models are thus developed for the prediction of Absorption, Distribution, Metabolism,
Excretion (ADME) properties at the early stages of drug discovery to decrease the fraction of global pharmacokinetics related failures in the later phases of drug development. Dihyropyrimidinone derivatives possess a broad spectrum of biological activities like Antibacterial, Antifungal, Antiviral, Anticancer Antihypertensive activities. The objective of this study is to predict Pharmacokinetic, drug likeness properties and toxicity of Dihydropyrimidinone derivatives by using Swiss adme, PKCSM, Lazar and Pro toxsoftware’s. All the compounds followed the Lipinski ‘Rule of five’ and showing good oral bioavailability. All the compounds were nontoxic except for Compound F6 which showed hepatotoxicity and reproductive toxicity.

Keywords: Dihydropyrimidinone derivatives; adme; Swiss ADME; PkCSM; Lazar; Protox.
 

References

No records found.


About this article

Cite this article

P Soma Yasaswi, P SaiHarshita, AnuradhaBai. Insilico Admet Predictions of Dihydropyrimidinones using Swiss Adme, Pkcsm, Lazar and Protox. J Pharmaceut Med Chem. 2020;6(1):21–26.
 

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6120.4

Keywords


Article Level Metrics

Last Updated

Monday 07 September 2026, 23:13:45 (IST)

1018

Accesses

6
100
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share