Home > Journals > Journal of Pharmaceutical and Medicinal Chemistry

Journal of Pharmaceutical and Medicinal Chemistry

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

In-Vitro Anti-Bacterial and Anti-Fugal Activity of a Novel Series of Quinoxaline 2, 3-Dione Derivatives

Sankari E , V Sandhiya1 , Sankari E2 , Remya RS3

Author Information

Licence:



Journal of Pharmaceutical and Medicinal Chemistry 6(2):p 49-67, July-December 2020. | DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6220.6

How Cite This Article:

V Sandhiya, Sankari E, Remya RS / In-Vitro Anti-Bacterial and Anti-Fugal Activity of a Novel Series of Quinoxaline 2, 3-Dione Derivatives. J Pharmaceut Med Chem. 2020;6(2):49-67.
 

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Aim: The aim of the present study is to synthesis and evaluation of anti-microbial activity of novel series of quinoxaline 2, 3 Dione derivatives containing a 2-azetidinone (A1-A5) nucleus. Method: The synthesis of azetidinones by reacting with chloroacetyl chloride in the presence of triethylamine. All the title compounds were tested for their anti-microbial activity against gram-positive (staphylococcus aureus, staphylococcus epidermidis, Bacillus cereus and pseudomonas aereginosa) and gram-negative (Escherichia coli and klebsiella pneumonia) bacteria, fungal activity against (Aspergillus Niger and Aspergillus fumigates) at a concentration of 100,200µg/ml. Result: Antibacterial activity of synthesized compounds was tested against both gram positive and gram negative bacteria and the standard drug used for the study was ciprofloxacin. The chloro, fluro and bromo substitution in three derivatives showed significant antifungal activity when compared to standard. The hydroxy, nitro groups showed mild activity when compared to standard. Conclution: A novel series of quinoxaline 2, 3- Dione derivatives has anti-microbial activity so supplementary exploration has been needed to establish other pharmacological performance of these derivatives and in future it would be a most promising and leading derivatives for several ailments. Keywords: Quinoxaline 2; 3-Dione; Antimicrobial activity; Anti-fungal activity; Schiff bases reactions.

References

No records found.


About this article

Cite this article

V Sandhiya, Sankari E, Remya RS / In-Vitro Anti-Bacterial and Anti-Fugal Activity of a Novel Series of Quinoxaline 2, 3-Dione Derivatives. J Pharmaceut Med Chem. 2020;6(2):49-67.
 

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.6220.6

Keywords


Article Level Metrics

Last Updated

Monday 07 September 2026, 23:52:59 (IST)

1018

Accesses

2
100
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share