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Hypoxia Inducible Factor-1 (HIF-1) and Cancer Progression: A Comprehensive Review

Assistant Professor (Stage III), Department of Physiology, Midnapore College, Midnapore, Paschim Medinipur, West Bengal 721101, India , Saptadip Samanta* , Barsha Dassarma** , Subhajit Jana** , Subham Rakshit** , Sarbar Ali Saha***

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Indian Journal of Cancer Education and Research 6(1):p 94-109, January-June 2018. | DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.6118.11

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Abstract

Hypoxia is characterized as a decrease oxygen levels in tissue, represents a fundamental pathophysiological condition in the microenvironment of solid tumors. The key component of hypoxia sensing in the cell is the hypoxia­inducible factor (HIF), a transcriptional activator that mediates adaptive responses to hypoxia. HIF is a heterodimer comprising an oxygen­regulated a­subunit (HIF­1a) and a constitutively expressed b­subunit (HIF­1b). HIF­1 activity increases in the majority of human cancers and acts as a master transcription factor that has received the most intense attention in the field of cancer biology. The stability and activity of HIF­1 are regulated by its post­translational modifications such as hydroxylation, ubiquitination, acetylation, and phosphorylation. HIF­I induces a series of genes that participate in angiogenesis, iron metabolism, glucose metabolism, and cell proliferation/survival. Some novel agents have been shown to be targeted  HIF­1 through a variety of molecular mechanisms and could represent a novel approach to cancer therapy. 


Keywords: Hypoxia­InducibleFactor­1;CancerProgression;  TherapeuticTarget

 

 

 

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DOI: DOI: http://dx.doi.org/10.21088/ijcer.2321.9815.6118.11

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