Abstract

Background: Acute pancreatitis is a common condition, frequently attributed to gallstones or alcohol consumption. Interestingly, while hypocalcemia is typically associated with acute pancreatitis, hypercalcemia-induced pancreatitis is a rare clinical picture. Even more uncommon is the role of hyperparathyroidism as the underlying cause.This case challenges the conventional understanding of pancreatitis and its etiology, highlighting an atypical presentation that rose from hyperparathyroidism, through sustained hypercalcemia, emerged as the unexpected culprit for acute pancreatitis, shedding light on a rare interplay between endocrine dysfunction and pancreatic inflammation. Case Description: We present a case of middle age patient, who developed acute pancreatitis with no history of alcohol use or gallstone disease. Lab Investigations revealed elevated serum calcium levels prompting further evaluation. Imaging studies confirmed the presence of parathyroid adenoma, implicating primary hyperparathyroidism as underlying cause of hypercalcaemia and subsequent pancreatitis. The patient underwent surgical excision of aroma with normal normalisation of calcium levels and resolution of symptoms thereafter. Clinical relevance: This case highlights a rare, but critical association between hyperthyroidism and acute pancreatitis, emphasising the importance of investigating parathyroid pathology in patients presenting with hypercalcaemia and pancreatitis. Early diagnosis and targeted management can prevent recurrent episodes and associated complications.

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