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HLH, Lymphoma, CMV and HLH : Heterogeneous Presentation of HLH in Lymphoma

Raghuveer Prabhu Santhakumara* , Raghuveer Prabhu Santhakumara* , Pavan Kumar Boyella* , Geeta Vidyadharan** , Indu R. N.** , Vinayak Munirathnam* , Rema G.* , Annu Susan George* , Vijay Kumar S.* , Neeraj Sidharthan*

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Indian Journal of Cancer Education and Research 3(2):p 71-74, Jul-Dec 2015. | DOI: DOI: https://dx.doi.org/10.21088/ijcer.2321.9815.3215.4

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Abstract

Hemophagocytic Lymphohistiocytosis is a condition in which often there is a diagnostic delay due to non-specific clinical manifestations. We recently had two cases of Lymphoma associated hemophagocytic syndrome(LAHS)- while one presented with hemophagocytic lymphohistiocytosis (HLH) the other case developed HLH after achieving a complete remission secondary to a complication of chemotherapy. The description of the cases is followed by relevant discussion of pertinent points. In this article, we want to highlight the importance of evaluating for a lymphoproliferative disorder in a case of HLH as well as considering HLH in patients with lymphoma who have unexplained constitutional symptoms and cytopenias.

Keywords: Hemophagocytic Lymphohistiocytosis; Diffuse Large B Cell Lymphoma; T/Nk Cell Lymphoma; Hodgkins Lymphoma; Cytomegalovirus. 

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DOI: DOI: https://dx.doi.org/10.21088/ijcer.2321.9815.3215.4

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