Home > Journals > Indian Journal of Genetics and Molecular Research

Indian Journal of Genetics and Molecular Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Gene Responsible for Emergence of Antifungal Resistance in Candida Spps. & Diagnosis: A Review

Tejpal , Kailash Chandra Semwal 1 , Mahima Kushwaha 2 , Tejpal 3 , Narotam Sharma 4

Author Information

Licence:



Indian Journal of Genetics and Molecular Research 10(2):p 39-45, JULY-DEC 2021. | DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.10221.1

How Cite This Article:

Kailash Chandra Semwal, Mahima Kushwaha, Tejpal, Narotam Sharma/Gene Responsible for Emergence of Antifungal Resistance in Candida Spps. & Diagnosis: A Review/Indian J Genet Mol Res. 2021; 10(2):39–45.

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Candida is a commensal & present in moist region of the human body. It also acts as an opportunistic pathogen that is prevalent in immunocompromised patients such as in case of HIV, hepatitis B, Cancer or also in diabetic patients. In COVID19 era, it also causes no. of cases in COVID19 patients due immunosuppression. It also known by name i.e. white fungus. The numbers of cases mainly increase in patients who are hospitalized due to the COVID19, because in hospital there are number of resistance organisms which are present in hospital environment.C. auris is reported in India but also in all over the world. Rise of antifungal resistance in Candida also become a big problem for public health sector. Due to this, Candida acquired resistance against azole, polynes & echinocandins. This resistance mechanism increased due to over expression of genes such as SNQ2, TPO3, ABC1, ERG11, ERG2, ERG3, ERG5, ERG6 which gain in function through mutation in the transcription that leads to alteration in gene expression that cause increase in drug efflux pumps, increased concentration of lanosterol 14α-demethylase & point alteration in which ergosterol content decreased in cells. Diagnosis can be done by multiplex PCR technique, to know the gene which responsible for antifungal drugresistance in that particular Candida specie.

 

References

No records found.


About this article

Cite this article

Kailash Chandra Semwal, Mahima Kushwaha, Tejpal, Narotam Sharma/Gene Responsible for Emergence of Antifungal Resistance in Candida Spps. & Diagnosis: A Review/Indian J Genet Mol Res. 2021; 10(2):39–45.

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.10221.1

Keywords

Candidemia; Antifungal drugs; COVID19; Co-infection; CHROMagar.

Article Level Metrics

Last Updated

Monday 22 June 2026, 05:01:38 (IST)

941

Accesses

2
274
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share