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Gellified Emulsion of Voriconazole for Transdermal Drug Delivery

Gandla Kumaraswamy* , Gandla Kumaraswamy* , G. Ramesh** , K. Vijay Prakash*

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Journal of Pharmaceutical and Medicinal Chemistry 3(1):p 15-31, January - June 2017. | DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.3117.3

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Abstract

Transdermal drug delivery has gained a tremendous interest in today´s pharmaceutical formulation design and still research is going on in achieving better product. Transdermal drug delivery system is having a plenty of advantages over other drug delivery system. Voriconazole is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections drug with biological half life of Dose Dependent with oral bioavaibality of 58%. The objective of the present study was to develop gellified emulsion of Voriconazole to decrease the systemic side effects and to create a more pronounced effect with lower doses of the drug. Gellified emulsion (Emulsion in gel) have emerged as one of the most interesting topical drug delivery system as it has dual release control system. Also the stability of emulsion is increased when it is incorporated into gel. The gellified emulsion was developed using polymers like carbopol 940 and HPMC K-100 in various ratios (1:1 and 1:1.5) of gel and emulsion.DSC and IR spectral studies were performed to confirm the compatibility of drug and polymers in the formulations. The prepared gellified emulsion was evaluated for their physical appearance, pH evaluation, spreadability, rheological study, drug content and in- vitro permeation studies. In-vitro drug permeation studies were carried out using keishary chein cell using egg membrane as the permeation membrane. The optimized formulations VE-4 and VE-4 showed Highest drug permeation as compared to other formulations and followed peppas with nonfickian as a best fit model in the drug release kinetics.The optimized formulations was subjected to stability studies as per ICH guidelines and concluded as stable formulations.

Keywords: Voriconazole; Emulgel; Carbopol 940; HPMC K-100.

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DOI: DOI: http://dx.doi.org/10.21088/jpmc.2395.6615.3117.3

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