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Editorial

Exploring the Automotive Analogy of Neoplastic Progression: How Do Cancer Cells 'Gear Up' to Evade & Invade?

Shilpee Dutt’s Lab, Tata Memorial Centre Advanced Centre for Treatment, Research and Education in Cancer, Kharghar, Navi Mumbai, Maharashtra 410210, India. , Anirudh V. Pillai

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Indian Journal of Cancer Education and Research 6(1):p 5-12, January-June 2018. | DOI:

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Abstract

 

Cancer is a multi­factorial and multi­step disorder driven by acquired mutations/defects in components that contribute to coordinating replication, behaviour and fate in the individual cells of multi­cellular body organizations. Ten ‘hallmark’ cellular defects have been broadly­documented in the chronologies of neoplastic progression from cancer cases, two of which have previously been compared to the malfunction of automobile pedals. Weinberg’s carcentric analogy is hereby extended to the other hallmark cellular defects and the inherent survival strategies that they employ, towards understanding transformation from the perspective of parallel mechanical defects that may plague the control network in an automobile during its ‘lifetime’, and how making timely repairs may prevent a catastrophic chain of dysfunctions in both systems, as they age.

Keywords: Cancer; Ageing; Car; Analogy.


 

 

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