Abstract

Synchronous malignancies often coincide with esophageal cancer, primarily within the
upper aerodigestive tract. The coexistence of esophageal cancer and renal cell carcinoma (RCC)
is exceptionally rare, with only 12 documented cases worldwide. Esophageal carcinomas
accompanied by synchronous malignancies exhibit a poorer prognosis than isolated esophageal
carcinoma, underscoring the significance of detecting synchronous RCC, as it significantly
influences the choice of treatment strategy.
Presented here is a case involving synchronous esophageal and RCC in a 62-year-old Indian
male. Following a review of literature, we propose that this case is likely the first reported
instance from India. The patient has been scheduled for radical nephrectomy, followed by
preoperative chemoradiation and esophagectomy.
This case report holds potential relevance in the expanding realm of research on possible
carcinogens in synchronous malignancies development. The simultaneous onset of esophageal
malignancy and RCC may be linked to the ingestion of a carcinogen excreted by the kidneys.

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