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Indian Journal of Anesthesia and Analgesia

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Efficacy of Epidural Clonidine as an Adjuvant to Local Anesthetic in Lower Abdominal Surgeries: A Randomized Control Clinical Trail

Sunil B.V., Associate Professor, Department of Anaesthesiology, Kasturba Medical College, Attaver, Mangalore, Karnataka 575003, India. , Ranjan Ramakrishna1 , Shalini S.2 , Sunil B.V.3 , Neeta S.4 , Sonal Bhat5

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Indian Journal of Anesthesia and Analgesia 5(2):p 259-264, February 2018. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5218.18

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Abstract

Introduction: Management of both intraoperative anaesthesia and post operative pain by neuraxial block demands addition of additives which gives good and prolonged postoperative analgesia with minimal side effects. Among various choices of additives, alpha 2 agonists are one among the preferred drugs. Aim of the Study: To compare the efficacy of a mixture of 0.5% bupivacaine and clonidine 150 micrograms with 0.5% bupivacaine used alone in lumbar epidural anaesthesia for lower abdominal surgeries. Materials and Methods: Fifty patients belonging to ASA I or ASA II category were selected for the study. All patients were randomly divided into two groups of 25 each. Group I, the control group received 10-15 ml 0.5%of bupivacaine and 1 ml of normal saline and Group II. Clonidine group received 10-15 ml of 0.5% bupivacaine and 150µgm of clonidine. Onset and duration of sensory and motor block and duration of post-operative analgesia along with adverse effect were studied. Statistical analysis was performed using student unpaired t –test and chi- square test. Results: Epidural clonidine in the dose of 150 µgm combined with 0.5% bupivacaine produced an effective anaesthesia with rapid onset, intensified and prolong blockade and an extended duration of post operative analgesia with minimum side effects.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.5218.18

Keywords

Clonidine; Bupivacaine; Extradural; Analgesia. 

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