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Indian Journal of Anesthesia and Analgesia

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Effects of Granisetron and Palonosetron on Haemodynamic Changes as Antiemetics

Roopa Hatti, Assistant Professor, Department of Anaesthesiology, Gulbarga Institute of Medical Sciences, Kalburgi, Karnataka-585101, India. , Anusha Dhage1 , Roopa Hatti1

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Indian Journal of Anesthesia and Analgesia 4(3):p 864-868, July - September 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4317.52

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Abstract

Introduction: The adverse reactions commonly reported for palonosetron were headache and constipation. All other reactions such as diarrhea, dizziness, abdominal pain, fatigue, insomnia occurred at an incidence of <1%. There were no electrocardiographic changes or dose response effects, including QTc prolongation due to palonosetron up to a 2.25 mg iv dose, a 9-fold safety margin. Methodology: In post anaesthesia care unit blood pressure and heart rate were recorded every 10 min for 30 min. Episodes of nausea and vomiting experienced by each patient were recorded by direct questioning. The number of patients who suffered nausea/vomiting were noted during the period’s 0-4hrs, 4-12hrs, and 12-24hrs in the post operative period and statistical analysis was done accordingly. Results: Systolic, Diastolic BP, Heart rate and oxygen saturation showed no statistically significant difference recorded in PACU between the study groups. Conclusion: The number of patients who suffered side effects was more in granisetron group.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4317.52

Keywords

Palonosetron; Granisetron; Blood Pressure. 

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