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Effects of Dexmedetomidine Infusion in different Concentrations on Intraoperative and Postoperative Hemodynamic Response and Analgesic Requirement in Laparoscopic Cholecystectomy Patients

Effects of Dexmedetomidine Infusion in different Concentrations on Intraoperative and Postoperative Hemodynamic Response and Analgesic Requirement in Laparoscopic Cholecystectomy Patients , Divya Mahajan1 , Ravi Goel2 , Nishi Kulshreshtha3 , Pavan Gurha4

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Indian Journal of Anesthesia and Analgesia 6(3):p 915-921, May-June 2019. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6319.32

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Divya Mahajan, Ravi Goel, Nishi Kulshreshtha et al. Effects of Dexmedetomidine Infusion in different Concentrations on Intraoperative and Postoperative Hemodynamic Response and Analgesic Requirement in Laparoscopic Cholecystectomy Patients. Indian J Anesth Analg. 2019;6(3):915-921.

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Abstract

Background: Dexmedetomidine is a newer α2 agonist with sedative, sympatholytic and analgesic properties. This study was carried out to evaluate the effect of two different concentrations of intravenous dexmedetomidine infusion on haemodynamic response to critical incidents like laryngoscopy, endotracheal intubation, creation of pneumoperitoneum and extubation in patients undergoing laparoscopic cholecystectomy. Methods: The study was conducted at our institute in 60 ASA grade I & II patients undergoing laparoscopic cholecystectomy. They were randomly allocated into two groups of 30 patients each ‘Group Dex 0.25’ and ‘Group Dex 0.5’. The patients received dexmedetomidine infusion at the rate of 0.25 /kg/hr and 0.5 mcg/kg/hr respectively, starting 15 minutes before induction and continued till the end of surgery. Standard anaesthesia technique was used. Comparison of the effect of infusion on haemodynamic changes seen in laparoscopic cholecystectomy was done. Results: Haemodynamic response to laryngoscopy and creation of pneumoperitoneum was blunted more in group Dex 0.5 as compared to group Dex 0.25. The intraoperative and post operative analgesic requirement was also reduced in group Dex 0.5. The time to first analgesic demand was later in the group Dex 0.5 as against group Dex 0.25. No significant side effects were noted in either group. Conclusion: Dexmedetomidine infusion at the rate of 0.5 mcg/kg/hr given perioperatively can serve as a very useful anaesthetic adjunct for premedication, maintenance of haemodynamic stability and postoperative analgesia without any significant adverse effects.

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Divya Mahajan, Ravi Goel, Nishi Kulshreshtha et al. Effects of Dexmedetomidine Infusion in different Concentrations on Intraoperative and Postoperative Hemodynamic Response and Analgesic Requirement in Laparoscopic Cholecystectomy Patients. Indian J Anesth Analg. 2019;6(3):915-921.

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.6319.32

Keywords

Dexmedetomidine; Laparoscopic cholecystectomy; Hemodynamics.

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