Home > Journals > Indian Journal of Genetics and Molecular Research

Indian Journal of Genetics and Molecular Research

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Effect of the Epigenetic Regulators (JAK2 and IDH-2) on the Methylation Status of Tumor Suppressor Genes (p15, FHIT, Calcitonin and SOCS-1) and Prognosis of MDS Patients: A Study from India

Rekha Chaubey , Rekha Chaubey 1 , Sudha Sazawal 2 , Manoranjan Mahapatra 3 , Sunita Chikkara 4 , Renu Saxena 5

Author Information

Licence:



Indian Journal of Genetics and Molecular Research 8(1):p 9-14, January-June 2019. | DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.8119.1

How Cite This Article:

Rekha Chaubey, Sudha Sazawal, Manoranjan Mahapatra et al. Effect of the Epigenetic Regulators (JAK2 and IDH-2) on the Methylation Status of Tumor Suppressor Genes (p15, FHIT, Calcitonin and SOCS-1) and Prognosis of MDS Patients: A Study from India. Indian J Genet Mol Res. 2019;8(1):9-14.

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

The Myelodysplastic Syndromes (MDS) are a group of clonal disorders of the hematopoietic system characterized by the presence of ineffective hematopoiesis, peripheral cytopenias and an increased risk of transformation to acute myeloid leukemia (AML). The pathogenesis of MDS involves a complex pattern of genetic, epigenetic and immune mediated mechanisms. However, recent advances in the understanding of the disease have identified altered epigenetic mechanisms, particularly aberrant DNA methylation as a key pathogenic factor in MDS. Since presently very sparse data is available on the epigenetic regulators and their effect on the methylation machinery, we studied the mutations in the epigenetic regulators i.e. JAK2V617F and IDH-2 ina series of 45 MDS patients and analyzed their effect on the methylation of the four tumor suppressor genes (p15, FHIT, calcitonin and SOCS-1) and clinical profile of MDS patients. We have found JAK2 mutation in 29% and IDH2 in 7% of MDS cases. JAK2 mutation was significantly correlated with the SOCS-1 gene methylation (p<0.05). No effect of IDH2 mutation on methylation was observed. Also, we did not find any correlation of co-occurrence of JAK2 /IDH2 mutation and SOCS -1 methylation on the prognosis and treatment outcome. Our study suggests the importance of epigenetic regulation of SOCS -1 methylation through JAK/STAT pathway in the leukemogenesis.

 

References

No records found.


About this article

Cite this article

Rekha Chaubey, Sudha Sazawal, Manoranjan Mahapatra et al. Effect of the Epigenetic Regulators (JAK2 and IDH-2) on the Methylation Status of Tumor Suppressor Genes (p15, FHIT, Calcitonin and SOCS-1) and Prognosis of MDS Patients: A Study from India. Indian J Genet Mol Res. 2019;8(1):9-14.

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijgmr.2319.4782.8119.1

Keywords

Epigenetic Regulators; JAK2; IDH-2; FHIT; Calcitonin and SOCS-1

Article Level Metrics

Last Updated

Monday 22 June 2026, 00:15:37 (IST)

941

Accesses

0
274
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share