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Indian Journal of Anesthesia and Analgesia

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Effect of Preemptive Intravenous Magnesium Sulphate on Post Operative Analgesia for Surgeries Done under General Anaesthesia: A Prospective Randomised Study

Santpur Madhavi Unmesh, Associate Professor, Department of Anaesthesia, Maharishi Markendeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana 133207 India. , Santpur Unmesh S.1 , Santpur Madhavi U.2 , Karri Laxmi Priyanka3

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Indian Journal of Anesthesia and Analgesia 4(4):p 1115-1120, October-December 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4417.32

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Abstract

Context: Effective postoperative analgesia is always a challenge. Drug therapies in vogue have their own merits and demerits. Thus a concept of preemptive analgesia has evolved. Aims: The present study was aimed to evaluate the efficacy of preemptive intravenous magnesium sulphate on post operative analgesia for surgeries done under general anaesthesia. Settings and Design: A prospective randomized double blind study. Methods and Material: Sixty patients of ASA grade I or II between 20 to 50 years age, of either gender were divided into two groups of 30 each. Group I received 40 mg/kg of intravenous infusion of magnesium sulphate preoperatively and 10 mg/kg/hr intraoperatively and Group II received same volume of normal saline preoperatively and intraoperatively. Statistical analysis used: Observations were analysed using‘students unpaired t-test’. Results: The pain score, sedation score at recovery and number of rescue analgesics required in 24 hours was observed. The decrease in pain scores and the higher level of sedation in group I was statistically significant (p<0.05). Conclusions: Preemptive magnesium sulphate significantly reduces postoperative pain, provides sedation and reduces analgesic requirement

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4417.32

Keywords

Preemptive; Intravenous Magnesium Sulphate; Postoperative Analgesia; Sedation. 

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