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Effect of Auto-Co-Induction of Propofol on Total Induction Dose and Haemodynamics

Shoba K., 68/11B, GNT Road, Sembulivarum, Chennai-600067. , C.B. Sridhar* , Sulochana Dash** , Shoba K.***

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Indian Journal of Anesthesia and Analgesia 4(2):p 537-541, April - June 2017. | DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.29

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Abstract

Introduction: Rapid induction with propofol causes fall in arterial pressure and tachycardia.Our study aims at comparing the hemodynamic changes between rapid dose and priming dose, measure propofol requirement and evaluate complications between the two groups. Materials and Methods: Hundred consecutive patients posted for elective surgery under general anaesthesia with endotracheal intubation were randomly divided into two groups of 50 patients each (Group I and II). Group I (priming dose) received 20% of the total calculated dose of inj. Propofol (2 mg/kg) and 30 seconds later the remaining calculated dose of propofol was injected at a rate of 30 mg/10 seconds till the loss of eyelash reflex and group II(rapid induction dose) were injected propofol at a speed of 30 mg/ 10sec until the loss of eyelash reflex. Heart rate, arterial pressure, total induction dose and complications were recorded. Results: The mean induction dose of propofol was 109.60 in group II and 90.84 in group I.The mean heart rate were higher and mean arterial blood pressure were lower in control group at one and three minute after induction compared to study group. It was also observed that 50% in  control group and 68% in study group had developed various complications. Discussion: In our study priming dose reduced the total induction dose requirement of propofol by 18%. There were lesser hemodynamic fluctuations with priming dose. Apnea and fasiculations were more in priming group. Conclusion: Priming principle requires lesser dose of propofol and prevents hemodynamic fluctuations caused due to propofol.
 

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DOI: http://dx.doi.org/10.21088/ijaa.2349.8471.4217.29

Keywords

Auto-coInduction; Priming Dose; Rapid Dose; Blood Pressure; Heart Rate.

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